by Behailu Asmamaw, Temesgen Tamiru Tadese, Rediet Yifru Mamo, Berhanu Amare Taye, Abrham Workineh Azale, Yohannes Chemere Wondmeneh, Dagmawi Nega Shibeshi, Eunice Borkor Bortequaye, Temesgen Teklu Ziza, Temesgen Esayas Bolliso, Tiwabwork Tekalign, Awoke Guadie
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by Maxime Golias, Zuzana Krupova, Pierre Defrenaix, Marie-Françoise Heymann, Dominique Heymann
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by Changze Ou, Haidong Yu, Binbin Chen, Huajun Long
BackgroundSepsis and atrial fibrillation are complex, life-threatening medical conditions affecting approximately 49 million individuals globally, characterized by exceptionally high mortality rates. Lipid metabolism abnormalities play a critical role in the pathogenesis of these diseases, yet their underlying molecular mechanisms remain incompletely understood.
ObjectiveThis innovative study systematically investigates the shared... Читать дальше...
by Muluwork Getahun, Yenew Kebede, Hilina Molalegn, Ayinalem Alemu, Getu Diriba, Waganeh Sinshaw, Mengistu Tadesse, Ephrem Tesfaye, Kassahun Belachew, Ameha Mekasha, Beniam Feleke
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by Mikail G. Alejandro, Kathleen Schultz, David W. Killilea
Circulating mineral concentrations are used to assess nutritional status or as markers for clinical conditions, but the quality of these measurements depends on the methods used for blood processing. Since the procedures for measuring mineral levels in blood are not standardized, discrepancies in sampling may influence the analytical results. We previously reported that zinc content in blood samples showed significant variation depending... Читать дальше...
by Francisca Mutapi, Ibrahima Socé Fall, Humphrey D. Mazigo, Paradzayi Tagwireyi, Hassan Ahmed Hassan Ahmed Ismael, Geoffrey Banda, Paul Erasto Kazyoba, Takafira Mduluza
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by Júlia Pereira Martins, Felipe Araujo Santos, Kelly Alves Bicalho, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype Magalhães, Maísa Aparecida Ribeiro, Renata Glória Sá, Lucas Pedreira de Carvalho, Antonio Carlos Rosário Vallinoto, Laurence Rodrigues Amaral, Anna Barbara de Freitas Carneiro-Proietti, Andréa Teixeira-Carvalho, Allyson Guimarães Costa, Olindo Assis Martins-Filho, Márcio Sobreira Silva Araújo
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by Shao Rong Long, Hui Ran Zhang, Jing Jing Wang, Zi Xuan Liao, Qi Xue Fan, Yu Qing Liang, Cheng Yu Gan, Ruo Dan Liu, Jing Cui, Xi Zhang, Zhong Quan Wang, Xin Qi
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by Henri Loshouarn, Alessandra A. Guarneri
Chagas disease, caused by the parasite Trypanosoma cruzi, is a major neglected tropical disease affecting 6–7 million people worldwide. Rhodnius prolixus, one of the most important vectors of Chagas disease in Latin America, is known to be highly sensitive to environmental temperature, which influences both its biology and parasite development. However, few studies have investigated how this vector behaviorally modulates the effects of temperature by shifting their thermopreference... Читать дальше...
by Peter S. Andrus, Li-min Yang, Qing-chi Han, Zhi-heng Qi, Zhi-ying Hou, Xiao-nen Wu, Si-yuan Liu, Kun Wang, Jun-hu Chen, Robbie Rae, Christopher M. Wade, Yun-hai Guo, Xiao-nong Zhou
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by Anuja Dokras, Christos Coutifaris, Alan T. Remaley, Nehal N. Mehta, Martin P. Playford, Allen R. Kunselman, Christy C. Stetter, William C. Dodson, Richard S. Legro
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by Conor Hession, Kevin P. Byrne, Kenneth H. Wolfe, Geraldine Butler
The budding yeast Saccharomyces cerevisiae has ‘point’ centromeres, which are much smaller and simpler than centromeres of most other eukaryotes and have a defined DNA sequence. Other yeast taxa have different and highly diverse centromere structures, but a clear picture of how yeast centromeres have evolved is lacking. Here, we investigated nine yeast species in two taxonomic orders that are close outgroups to S. cerevisiae. Читать дальше...
by Gota Morishita, Carsten Murawski, Nitin Yadav, Shinsuke Suzuki
Learning by observing others’ experiences is a hallmark of human intelligence. While the neurocomputational mechanisms underlying observational learning are well understood, less is known about whom people prefer to learn from in the context of observational learning. One hypothesis posits that learners prefer individuals who exhibit a high degree of decision noise, ‘free riding’ on the costly exploration of others. An alternative... Читать дальше...
by Giuseppe Marrazzo, Federico De Martino, Albert Mukovskiy, Martin A. Giese, Beatrice de Gelder
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by Rainey Lyons, Vanja Dukic, David M. Bortz
Characteristics of individuals in a population, such as age and size, play a key role in determining how populations change over time. In contexts of population dynamics, identifying effective model features, such as fecundity and mortality rates, is generally a complex and computationally intensive process, especially when the dynamics are heterogeneous across the population. In this work, we propose a Weak form Scientific Machine Learning-based... Читать дальше...
by Dmitry Amakhin, Anton Chizhov, Guillaume Girier, Mathieu Desroches, Jan Sieber, Serafim Rodrigues
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by Fang Ye, Zhiyi Zhang, Binghao Zhang, Xinyu Li, Jiaxi Deng, Qian Miao, Peiruo Ning, Yunlin Chi, Geng Chen, Zhangsong Wu, Qian Wang, Lezhi Xu, Ningjie Gong, Bangning Cheng, Zhigang Ma, Chungen Qian, Lizhe Zhu, Xin Pan, Yang Du
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by Eudald Pascual-Carreras, Kathrin Garschall, Patrick R. H. Steinmetz
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by Alexandra A.-T. Weber
The traditional pipeline view of academia no longer reflects the reality of scientific careers. Reframing success as a network of paths recognizes excellence in its many forms, fostering a more inclusive, resilient, and socially engaged research culture. The traditional pipeline view of academia no longer reflects the reality of scientific careers. This Perspective reframes success as a network of paths recognizes excellence in its many forms, with the aim of fostering a more inclusive... Читать дальше...
by Longqiang Wang, Xiao Wu, Atanu Paul, Jun Yao, Bin Wang
The breast and ovarian tumor suppressor BRCA1 is a cell cycle-regulated protein and tumors with reduced BRCA1 protein level may share molecular features of BRCA1-mutant tumor and respond to PARPi therapy. Here, we identify that BRCA1 protein stability is controlled through ubiquitin lysine 11 (K11)-linkage modification under the regulation of Cezanne deubiquitinating enzyme, APC/C E3 ligase, and Ube2S E2 conjugating enzyme in a cell cycle-dependent manner. Читать дальше...
by Silke Stertz, Umut Karakus
Zoonotic spillover of influenza A viruses represents a threat to human health. Emerging research suggests that some influenza A viruses can enter host cells via MHC-II across species, potentially increasing spillover risk. Spillover of influenza A viruses from animals to humans represents a threat to our health. This Perspective discusses emerging research that suggests some influenza A viruses can enter host cells via MHC-II across species, reflecting on the... Читать дальше...
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