This randomized trial assesses whether acetaminophen would increase the number of days alive and free of organ support to day 28 among critically ill patients with sepsis and respiratory or circulatory organ dysfunction.
This randomized clinical trial compares the efficacy and safety of pamrevlumab vs placebo for patients with idiopathic pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that inevitably results in respiratory failure and death within 3 to 5 years of diagnosis. No effective treatment for IPF existed until the approval of 2 antifibrotic drugs (pirfenidone and nintedanib) more than 10 years ago. These drugs were approved by the US Food and Drug Administration based on demonstration of significant drug-associated differences in slowing the decline in lung function in 2 randomized clinical trials;... Читать дальше...
In this narrative medicine essay, a patient who has outlasted all the other patients with her diagnosis cannot explain why or how she has survived and decides to commemorate her good fortune with a long walk from her home to the hospital.
This Viewpoint from AHRQ describes the plan to create a national health care extension service to disseminate actionable knowledge, with a goal to reduce the gap from evidence of clinical effectiveness to clinical practice.
This randomized clinical trial assessed whether adding dapagliflozin to standard care for patients with acute organ dysfunction could reduce the composite outcome of hospital mortality, initiation of kidney replacement therapy, and length of stay compared with standard care alone.
Multisystem organ dysfunction can follow several acute injury mechanisms, including trauma, sepsis, and shock and is the leading cause of death in critically ill patients. Even after the initial cause of organ injury has been addressed, many organs remote from the initial injury remain “on strike” for days or even weeks, often despite little evidence of direct injury. There are no specific treatments to prevent or reverse this organ dysfunction, so supportive care is the cornerstone of treatment in the intensive care unit (ICU).
This JAMA Clinical Guidelines Synopsis summarizes the American College of Chest Physicians’ 2022 guideline on perioperative management of patients taking oral anticoagulation or antiplatelet therapy who are undergoing an elective surgery or procedure.
This Special Communication discusses the current clinical trials system, examines why payers should support evidence generation, and suggests potential avenues for collaboration.
This Viewpoint discusses the need to include patient and health care professional perspectives in the design of clinical trials to improve trial features and implementation.
This Viewpoint discusses the potential challenges to the operational conduct of clinical trials in the Asia-Pacific region, where there is a high rate of cardiovascular disease, and provides possible solutions.
To the Editor A recent trial concluded that hyperangulated video laryngoscopy might be a preferable method for single-lumen endotracheal intubation in surgical procedures, compared with direct laryngoscopy. Although this conclusion aligns with a recent study, we have several concerns about this trial.
This study surveys a representative US population about aspects of hospital-at-home care, including acceptability and willingness to perform caregiving tasks.
This JAMA Insights discusses the diagnostic evaluation and treatment, including pharmacological, nonpharmacological, and surgical options, of essential tremor.
In the Original Investigation titled “Red Blood Cell Transfusion in the Intensive Care Unit,” published in the November 21, 2023, issue of JAMA, a nonauthor collaborator’s name was listed incorrectly. In Supplement 3, the name should have appeared as Filippo Sanfilippo. This article was corrected online.
This Viewpoint explores the use of relative value units assigned by the Resource-Based Relative Value Scale in US physician payment systems and the need to rebuild this scale to reflect changes in modern clinical practice.
You take the stairs now on all fours while step-by-slow-step I march behind your swollen legs and spider veins to guard against a fatal fall. Intact, we reach our painful routine: nightgown, pillbox, toothbrush, toilet; cat box, litter, bag of poop. Beguiling us to care for you, dementia’s filched the woman we knew. What can I do, flatfooted here between love and rage, but place, gently, the pathetic teddy, a kiss to your brow.
In this Medical News interview, Sachin Kheterpal, the University of Michigan Medical School’s associate dean for research information technology, joins JAMA Editor in Chief Kirsten Bibbins-Domingo to discuss AI’s number-crunching potential for improving patient care.
This JAMA Patient Page describes the causes, symptoms, risk factors, diagnosis, and treatment of food allergies.
Only a few years have elapsed since the existence of vitamins was first brought prominently to attention. The claims for the existence of such accessory food factors were received with skepticism for some time, for it seemed unlikely that substances playing a prominent part in nutrition could have escaped recognition so long. Most of the earlier observations and deductions have now been tested repeatedly and found to be correct. Within less than a decade after Funk coined the word vitamin, he felt... Читать дальше...
This Medical News story discusses the makeup of this fall’s updated COVID-19 vaccines.
There’s little evidence that taking metformin affects the risk of birth defects among children. Now, a pair of studies in Annals of Internal Medicine suggests that neither maternal nor paternal metformin use increases the risk of congenital malformations.
Receiving medications such as methadone and buprenorphine for opioid use disorder was linked with a lower risk of dying from a drug overdose among Medicare beneficiaries who experienced a nonfatal overdose during the prior year, a new cohort study involving more than 136 700 participants with an average age of 68 years found.
The prevalence of people aged 65 years or older with type 1 diabetes has risen globally over the past 30 years, from 400 older adults per 100 000 in 1990 to 514 older adults per 100 000 in 2019, a recent population-based analysis found. Deaths from the condition fell over the same period, as did disability-adjusted life-years, although not as quickly as mortality rates.
People who participated in a year-long intensive strength-training program maintained their leg strength over 4 years, while those who engaged in less-intensive resistance training or no training at all experienced a decline in strength, according to a recent randomized clinical trial involving 369 participants in Denmark with an average age of 71 years.
