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Новости за 04.12.2024

Plos.org 

Investigation into the mechanical properties and impact tendency of coal-rock composite structures with peridynamics: A study on predicting the occurrence tendency of dynamic pressure in coal-rock structures

by Jinqiu Dai, Mingchao Zhao, Zhenkang Wang, Han Gao

Due to the difficulty in predicting the occurrence of rockburst in deep mining areas,this paper proposes that the use of Peridynamics to analyze the mechanical characteristics of coal-rock composite structures under loading conditions from the perspective of energy, Determine the impact tendency of coal rock composite structures by combining rock elastic deformation energy index (WET) and rock impact energy index (WCF); Use Lammps software... Читать дальше...

Plos.org 

The drug risks of cilostazol: A pharmacovigilance study of FDA Adverse Event Reporting System database

by Lufeng Peng, Xueli Li, Junhai Li, Shibin Liu, Gang Liang

Objective

Cilostazol is indicated for alleviating intermittent claudication (IC) in stable-phase peripheral arterial disease (PAD) patients. Conducting data mining on adverse events (AEs) of cilostazol in the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database to explore its potential medication risks and advance more rational and secure clinical medication practices.

Methods

This study... Читать дальше...

Plos.org 

Climate-based modelling and forecasting of dengue in three endemic departments of Peru

by Cathal Mills, Christl A. Donnelly

Amid profound climate change, incidence of dengue continues to rise and expand in distribution across the world. Here, we analysed dengue in three coastal departments of Peru which have recently experienced public health emergencies during the worst dengue crises in Latin American history. We developed a climate-based spatiotemporal modelling framework to model monthly incidence of new dengue cases in Piura, Tumbes, and Lambayeque over 140 months from 2010 to 2021. Читать дальше...

Plos.org 

A regression based approach to phylogenetic reconstruction from multi-sample bulk DNA sequencing of tumors

by Henri Schmidt, Benjamin J. Raphael

Motivation

DNA sequencing of multiple bulk samples from a tumor provides the opportunity to investigate tumor heterogeneity and reconstruct a phylogeny of a patient’s cancer. However, since bulk DNA sequencing of tumor tissue measures thousands of cells from a heterogeneous mixture of distinct sub-populations, accurate reconstruction of the tumor phylogeny requires simultaneous deconvolution of cancer clones and inference of ancestral relationships, leading to a challenging computational problem. Читать дальше...

Plos.org 

Measuring genetic diversity across populations

by Niloufar Abhari, Caroline Colijn, Arne Mooers, Paul Tupper

Diversity plays an important role in various domains, including conservation, whether it describes diversity within a population or diversity over a set of species. While various strategies for measuring among-species diversity have emerged (e.g. Phylogenetic Diversity (PD), Split System Diversity (SSD) and entropy-based methods), extensions to populations are rare. An understudied problem is how to assess the diversity of a collection... Читать дальше...