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Новости за 16.12.2024

Cнегоходы, баня, рыбалка: чем заняться в Cosmos Collection Altay Resort
Джастин и Хейли Бибер выложили новые фото
Виктория Толстоганова, Игорь Верник, Александр Цыпкин, Павел Тбаков на «БеспринцЫпных чтениях. Версия будущего»
Cardi B и ее бывший муж Offset воссоединились, чтобы отпраздновать его 33-й день рождения
Театр танца «Лайм» приглашает на незабываемый Новогодний концерт
Бьюти-эволюция: как менялась внешность Анны Седоковой
Plos.org 
En

Estimating and visualising multivariable Mendelian randomization analyses within a radial framework

by Wes Spiller, Jack Bowden, Eleanor Sanderson

Background

Mendelian randomization (MR) is a statistical approach using genetic variants as instrumental variables to estimate causal effects of a single exposure on an outcome. Multivariable MR (MVMR) extends this to estimate the direct effect of multiple exposures simulatiously. MR and MVMR can be biased by the presence of pleiotropic genetic variants in the set used as instrumental variables, violating one of the core IV assumptions. Genetic... Читать дальше...

Кто может рассчитывать на выплату годовой премии, ответил юрист
Похищено следственным путем // Следователь СКР Избенко предстал перед судом за кражу вещдоков
Сотрудники «СитиИнвестГрупп» очистили Псков после утренней метели
Псковский суд установил истинную причину увольнения чиновника
«Постскриптум»: Партийные съезды, финишная прямая принятия бюджета и продолжение муниципальной реформы. ВИДЕО
Все для судейства и победы // В Воронеже повторно изучат уголовное дело о подкупе футбольных арбитров
Plos.org 
En

Neuro-cognitive multilevel causal modeling: A framework that bridges the explanatory gap between neuronal activity and cognition

by Moritz Grosse-Wentrup, Akshey Kumar, Anja Meunier, Manuel Zimmer

Explaining how neuronal activity gives rise to cognition arguably remains the most significant challenge in cognitive neuroscience. We introduce neuro-cognitive multilevel causal modeling (NC-MCM), a framework that bridges the explanatory gap between neuronal activity and cognition by construing cognitive states as (behaviorally and dynamically) causally consistent abstractions of neuronal states. Multilevel causal modeling... Читать дальше...

Plos.org 
En

Dopamine facilitates the response to glutamatergic inputs in astrocyte cell models

by Thiago Ohno Bezerra, Antonio C. Roque

Astrocytes respond to neurotransmitters by increasing their intracellular Ca2+ concentration (Ca2+ signals). While glutamate released by neurons trigger Ca2+ signals through IP3- and glutamate transporter-dependent mechanisms, dopamine released in distant sites activates astrocytes via dopaminergic receptors. However, little is known about the modulatory effects of dopamine on glutamate-evoked astrocytic activity. To investigate this question, we developed multi-compartment... Читать дальше...

Plos.org 
En

SLMO transfers phosphatidylserine between the outer and inner mitochondrial membrane in Drosophila

by Siwen Zhao, Xuguang Jiang, Ning Li, Tao Wang

Phospholipids are critical building blocks of mitochondria, and proper mitochondrial function and architecture rely on phospholipids that are primarily transported from the endoplasmic reticulum (ER). Here, we show that mitochondrial form and function rely on synthesis of phosphatidylserine (PS) in the ER through phosphatidylserine synthase (PSS), trafficking of PS from ER to mitochondria (and within mitochondria), and the conversion of PS to... Читать дальше...

Plos.org 
En

Engineering microbiomes for enhanced bioremediation

by Xihui Xu, Jiandong Jiang

Bioremediation using synthetic microbiomes offers significant advantages over traditional single-strain-based approaches. In this Perspective, we outline 5 important considerations for the rational design of pollutant-degrading microbiomes for enhanced bioremediation. Bioremediation using synthetic microbiomes offers significant advantages over traditional single‐strain‐based approaches. In this Perspective, the authors outline five important considerations for... Читать дальше...