This randomized clinical trial compares the effect on child weight-for-length trajectory of adding a digital childhood obesity prevention intervention to health behavior counseling delivered by pediatric primary care clinicians.
This prespecified, retrospective observational cohort study examines the trends in inferior vena cava filter insertion and retrieval for the prevention of venous thromboembolism among US Medicare beneficiaries.
The 1976 Medical Device Amendments granted the US Food and Drug Administration (FDA) regulatory authority over medical devices. The FDA’s regulatory review requirements are intended to correspond to the amount of information needed to provide “reasonable assurance of device safety and effectiveness” and establish a 3-tiered system for classifying devices based on their risk profile (low, moderate, and high) with a corresponding degree of evidence required for review. Low-risk devices are typically only subject to general controls (eg... Читать дальше...
This study analyzes the extent and persistence of payments to physicians from competing manufacturers after receipt of payment from manufacturers of first-in-class products entering 6 novel therapeutic classes.
This study assesses whether online vaping retailers adhere to age verification, shipping method, and flavor restrictions in California.
This Medical News article discusses a popular bystander training program for on-the-job mental health crises.
In recent decades obesity rates among US adults has climbed from 14% to 40%, with correspondingly high rates of obesity in children. Being overweight or obese in childhood is highly predictive of cardiometabolic disease in adults. The American Heart Association recently projected that by 2050 the adult prevalence of diabetes will increase from 16.3% to 26.8% and obesity from 43.1% to 60.6%, with obesity rates in children predicted to increase from 20.6% in 2020 to 33.0% in 2050 and with nearly 60%... Читать дальше...
This Viewpoint discusses the increasing popularity of taking a gap year between college and medical school and raises questions about the perceived necessity of this trend, its financial and other costs, and the potential disadvantage it may pose to underrepresented minority applicants.
This Viewpoint discusses the importance of teaching health policy to medical students so they can be informed on the everyday policy issues that patients may ask them about or for which their specialty societies may ask them to lobby.
This Special Communication analyzes and compares development times, clinical trial success rates, research and development costs, patent protection, market exclusivity periods, revenues, and treatment costs of biologics with small-molecule drugs.
This Appendix presents 2023 National GME Census data detailing the numbers and types of ACGME-accredited training programs and the residents and fellows in them.
This Appendix presents data derived from the 2023-2024 Liaison Committee on Medical Education Annual Medical School Questionnaire-Part II.
The ghazal is an ancient poetic form thought to have originated in 7th-century Arabic, and which later spread to medieval Persia via the work of the famed mystical poets Rumi and Hafez. In modern times, it is frequently performed in song in countries such as Iran and Pakistan, and has been brought into English by a number of contemporary poets, perhaps most notably by Agha Shahid Ali. The form typically consists of long-lined couplets with a repeated end word or phrase concluding each; the final... Читать дальше...
In mind, a world comes to life, one not to be revived except in mind, the end on its dauntless way, little else remaining to ponder.
In Reply We appreciate the letter from Ms Chen and colleagues about our article. First, differences in intensity of lifestyle interventions can affect weight reduction efficacy, with initial weight loss at 1 year ranging from −2% to −9%. Chen and colleagues ask about the efficacy of lifestyle interventions in our trial compared with results from the DIADEM-I and Look AHEAD trials, both of which included intensive lifestyle interventions. Our trial, similar to others investigating the efficacy and safety of antiobesity medications... Читать дальше...
To the Editor A recent study reported that once-weekly treatment with tirzepatide can effectively lead to weight reduction. However, we have several concerns about this article. First, the effect of lifestyle in this study requires further exploration. Among patients receiving tirzepatide, there was a weight reduction of 11.3% to 15.1% compared with placebo. All patients underwent lifestyle intervention, and after 52 weeks of treatment, the placebo group had only a 2.3% reduction in body mass. Although the populations in the studies differed... Читать дальше...
During the long history of diabetes there has probably been no period during which it was subjected to the intensive study that has been accorded it since the discovery of insulin. Clinicians have long recognized the extent of the menace that diabetes represents. It is not merely the death of a small army of persons each year from diabetes that makes the situation formidable; the disorder incapacitates a further great army of otherwise normal persons. Consequently it becomes a public duty to awaken the nation and also the medical profession... Читать дальше...
In Reply We agree with Dr Vercellini and colleagues, as stated in our original article, that the results of a single report should not change clinical care. We also agree that both clinical decisions and public health recommendations should consider absolute risks and therefore we reported risk differences in addition to hazard ratios. It is worth emphasizing that most women with endometriosis never develop ovarian cancer.
To the Editor As noted by Dr Barnard and colleagues, existing evidence confirms that endometriosis is associated with an elevated risk of ovarian cancer with differences by histotype. However, despite the varying presentations of endometriosis—most notably 3 macrosurgically visualized subphenotypes (endometriomas, superficial peritoneal, and/or deep lesions)—identifying women with endometriosis who are at high risk remains elusive. To address this question, the investigators leveraged data from the... Читать дальше...
To the Editor On behalf of my coauthors, I write to address concerns raised by a reader regarding the data presented in the Supplement to our Original Investigation, “Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis: The BASIS Randomized Clinical Trial,” published online first on September 5, 2024, and in the October 1, 2024, print/online issue of JAMA. We value the feedback and have conducted a thorough review of the data, specifically supplemental Tables S2, S3, and S12.
In the Original Investigation “Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis: The BASIS Randomized Clinical Trial,” published Online First September 5, 2024, and in the October 1, 2024, print/online issue of JAMA, there were errors in Tables S2, S3, and S12 in the Supplement. The author has explained these errors and corrections needed in a Letter to the Editor and has confirmed that there are no other errors in the article.
In this narrative medicine essay, an infectious diseases physician shares how her journey to and through a depressive episode led her to raise awareness of mental health challenges and to help create supportive working environments.
This JAMA Patient Page describes the parasitic infection Chagas disease and its risk factors, symptoms, diagnosis, and treatment.
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
