3D maps of diseased tissues at subcellular precision

Researchers in the Systems Biology Lab of Professor Nikolaus Rajewsky, at the Max Delbrück Center, have developed a spatial transcriptomics platform, called Open-ST, that enables scientists to reconstruct gene expression in cells within a tissue in three dimensions. The platform produces these maps with such high resolution, that researchers are able to see molecular and (sub)cellular structures that are often lost in traditional 2D representations. The study was published in Cell.