Biologists determine the Leep2 complex regulates macropinosome formation

The social amoeba Dictyostelium discoideum is a valuable model to study the regulation of macropinocytosis. A research team led by Prof. Cai Huaqing from the Institute of Biophysics of the Chinese Academy of Sciences has recently used the Dictyostelium model system and a proteomics-based approach to reveal the molecular mechanism of macropinosome formation controlled by Ras signaling.