Medical Management vs Bariatric Surgery in Type 2 Diabetes—Reply

In Reply We agree with Dr Fujieda that weight during childhood and adolescence is an important phenotypic variable, given that birth weight and early-life weight trajectories are associated with risk of obesity, type 2 diabetes, and cardiovascular outcomes. Unfortunately, the ARMMS-T2D Collaborative study, which pooled data from 4 separate randomized clinical trials, did not collect weight trajectory data from participants for the years prior to their enrollment in these studies. Future studies that are adequately powered to address cardiovascular health outcomes could include early-life weight trajectories as a potential mediating factor.