Effect of C-reactive protein on the risk of Heart failure: a mendelian randomization study

Research Open access Published: 07 March 2023 Danial Habibi1, Maryam S Daneshpour2, Sara Asgarian2, Karim Kohansal3, Farzad Hadaegh3, Marjan Mansourian4 & …Mahdi Akbarzadeh2,5 BMC Cardiovascular Disorders volume23, Articlenumber:112 (2023) Cite this article 3768 Accesses 6 Citations 2 Altmetric Metrics details AbstractBackgroundTraditional observational studies have shown positive associations between c-reactive protein (CRP) and heart failure (HF) risk. However, this association has not been fully elucidated. Therefore, Mendelian randomization was used to examine CRP’s possible etiological roles with HF.MethodsWe implemented a two-sample Mendelian randomization framework to examine the causality of the association between CRP and HF based on summary statistics by large-scale genome-wide association studies (GWAS) datasets of European ancestry through inverse-variance weighted, weighted median, MREgger regression, and MR-PRESSO methods. The summary statistics dataset on the association...