Tumor suppressor protein Par-4 triggers unique cell death pathway in cancerous cells

A team of researchers has discovered that the tumor suppressor protein Prostate apoptosis response-4 (Par-4) can cause a unique type of cell death called ferroptosis in human glioblastoma -- the most common and aggressive type of brain tumor -- while sparing healthy cells. This new understanding has the potential to inform the development of novel treatments for various hard-to-treat cancers and neurodegenerative diseases.