Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review

Review Open access Published: 06 January 2022 Tatiana Barichello ORCID: orcid.org/0000-0001-7776-84541,2, Jaqueline S. Generoso1, Mervyn Singer3 & …Felipe Dal-Pizzol1 Critical Care volume26, Articlenumber:14 (2022) Cite this article 93k Accesses 140 Citations 50 Altmetric Metrics details A Correspondence to this article was published on 08 April 2022 AbstractA biomarker describes a measurable indicator of a patient's clinical condition that can be measured accurately and reproducibly. Biomarkers offer utility for diagnosis, prognosis, early disease recognition, risk stratification, appropriate treatment (theranostics), and trial enrichment for patients with sepsis or suspected sepsis. In this narrative review, we aim to answer the question, "Do biomarkers in patients with sepsis or septic shock predict mortality, multiple organ dysfunction syndrome (MODS), or organ dysfunction?" We also discuss the role of pro- and anti-inflammatory biomarkers and biomarkers associated with intestinal...