SGL-2 Therapy for Acute Organ Dysfunction

Multisystem organ dysfunction can follow several acute injury mechanisms, including trauma, sepsis, and shock and is the leading cause of death in critically ill patients. Even after the initial cause of organ injury has been addressed, many organs remote from the initial injury remain “on strike” for days or even weeks, often despite little evidence of direct injury. There are no specific treatments to prevent or reverse this organ dysfunction, so supportive care is the cornerstone of treatment in the intensive care unit (ICU).