Construction and investigation of all-in-one microneedles complexed with functionalized polydiacetylene liposomes

Researchers have developed a novel detection platform that complexed polydiacetylene (PDA) liposomes with swellable microneedles (MNs) for the sensitive and non-invasive detection of biomarkers. The PDA liposomes, prepared using 10,12-Pentacosadiynoic acid (PCDA), exhibit unique optical properties that change in response to external stimuli such as temperature and pH. These changes include color shifts and fluorescence signal generation, which are harnessed for detection purposes.