Engineering hypoallergenic cats: Mutations found in South African cats suggest allergen expression may not be essential

Gene editing could create hypoallergenic cats, according to a sequence analysis of the protein that triggers allergies to cats. Some 15% of people are allergic to cats, and symptoms can be severe. Martin D. Chapman and colleagues investigated CH1 and CH2, genes that code for the allergen, Fel d 1. The work is published in the journal PNAS Nexus.