Pancreatic Adenocarcinoma Mutation Trajectories at Single Cell Resolution

Single cell RNA sequencing is nearly ubiquitous; single cell DNA sequencing has been much rarer.  I'm going to dive in a bit - but not a full review - of a recent paper which described single cell DNA sequencing of pancreatic ductal adenocarcinomas.  The paper applied the Mission Bio droplet-based PCR approach, which hasn't had quite the buzz of its close technological cousin 10X Genomics.  And there are some interesting implications of the findings in this paper to impending developments in oncology therapeutics - including one in which I have more than academic interest.Read more »