Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro

https://doi.org/10.3390/v14092080 · Видання: Viruses, 2022, №9, с.2080 Видавець: MDPI AG Автори: Guangming Ren Liming Xu Jingzhuang Zhao Yizhi Shao Yujie Lin Linfang Li Qi Liu Tongyan Lu Qiya Zhang Анотація Both infectious hematopoietic necrosis virus (IHNV) and infectious pancreatic necrosis virus (IPNV) are the causative agents of acute and highly contagious diseases of juvenile salmonids, resulting in severe economic losses to these cold-water fish globally. There is an urgent need to explore antiviral agents against IHNV and IPNV due to the lack of commercially available vaccines and antiviral drugs. More importantly, the co-infection of IHNV and IPNV is prevalent in nature, which not only aggravates extensive damage to the salmonids but also poses challenges to its prevention and control. The antiviral effects of a crude polysaccharide derived from seaweed (CSP) on IHNV and IPNV were evaluated in this study separately. Furthermore, the underlying antiviral mechanisms of CSP to IHN...