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Новости за 20.05.2024

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Assessing the reduction of viral infectivity in HPV16/18-positive women after one, two, and three doses of Gardasil-9 (RIFT): Study protocol

by Victoria López-Codony, Álvaro de Andrés-Pablo, Angelica Ferrando-Díez, Maria Eulàlia Fernández-Montolí, Marta López-Querol, Sara Tous, Carlos Ortega-Expósito, Juan Carlos Torrejón-Becerra, Yolanda Pérez, Anna Ferrer-Artola, Josep Maria Sole-Sedeno, Clara Grau, Blas Rupérez, Maria Saumoy, Mónica Sánchez, Paula Peremiquel-Trillas, Laia Bruni, Laia Alemany, Francesc Xavier Bosch, Miquel Angel Pavón

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Зумеры запустили безумный тренд – прыгать в мусорные баки
Наталья Страшнова стала ведущей программы «Формула Верхневолжья».
Врач-стоматолог Татьяна Сумцова: какие меры профилактики помогут от трещин
«Король Лир» Сергея Потапова стал победителем VIII фестиваля нового российского кино «Горький fest»
Вечная классика: чем привлекает улица Ильинка
В Магнитогорске из реки выловили женский труп с привязанным к нему грузом
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C-reactive protein and high-sensitivity C-reactive protein levels in asymptomatic intestinal parasite carriers from urban and rural areas of Gabon

by Helena Noéline Kono, Mérédith Flore Ada Mengome, Bedrich Pongui Ngondza, Roger Hadry Sibi Matotou, Luccheri Ndong Akomezoghe, Bernadette Ekomi, Bridy Chesly Moutombi Ditombi, Jeanne Vanessa Koumba Lengongo, Jacques Mari Ndong Ngomo, Noé Patrick M’Bondoukwé, Cyrille Bisseye, Denise Patricia Mawili-Mboumba, Marielle Karine Bouyou Akotet

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Dynamics of emergence and genetic diversity of dengue virus in Reunion Island from 2012 to 2022

by Etienne Frumence, David A. Wilkinson, Raphaelle Klitting, Muriel Vincent, Nicolas Mnemosyme, Gilda Grard, Nicolas Traversier, Ghislaine Li-Pat-Yuen, Diana Heaugwane, Laurent Souply, Claude Giry, Marie-Claire Paty, Louis Collet, Local Laboratory Network , Patrick Gérardin, Fabian Thouillot, Xavier De Lamballerie, Marie-Christine Jaffar-Bandjee

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Подожженный из-за спора о футболе 60-летний томич умер в реанимации
Москвичку со свернувшейся кровью спасли новосибирские врачи
Мыс Немецкий и Кекурский, и заброшенный поселок Мыс Скорбеевский. Путешествие на Дастере на полуостров Рыбачий и Средний. День третий
Новосибирец избавил собаку от одиночества с помощью смерти
Свыше 670 административных дел о нарушениях при временном ввозе автомобилей возбудили псковские таможенники
Новосибирцы предпочитают покупать импортные автомобили
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Bridging the gap between the evolutionary dynamics and the molecular mechanisms of meiosis: A model based exploration of the PRDM9 intra-genomic Red Queen

by Alice Genestier, Laurent Duret, Nicolas Lartillot

Molecular dissection of meiotic recombination in mammals, combined with population-genetic and comparative studies, have revealed a complex evolutionary dynamic characterized by short-lived recombination hotspots. Hotspots are chromosome positions containing DNA sequences where the protein PRDM9 can bind and cause crossing-over. To explain these fast evolutionary dynamic, a so-called intra-genomic Red Queen model has been proposed, based... Читать дальше...

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Queuosine biosynthetic enzyme, QueE moonlights as a cell division regulator

by Samuel A. Adeleye, Srujana S. Yadavalli

In many organisms, stress responses to adverse environments can trigger secondary functions of certain proteins by altering protein levels, localization, activity, or interaction partners. Escherichia coli cells respond to the presence of specific cationic antimicrobial peptides by strongly activating the PhoQ/PhoP two-component signaling system, which regulates genes important for growth under this stress. As part of this pathway, a biosynthetic enzyme called QueE... Читать дальше...

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Interpretable metric learning in comparative metagenomics: The adaptive Haar-like distance

by Evan D. Gorman, Manuel E. Lladser

Random forests have emerged as a promising tool in comparative metagenomics because they can predict environmental characteristics based on microbial composition in datasets where β-diversity metrics fall short of revealing meaningful relationships between samples. Nevertheless, despite this efficacy, they lack biological insight in tandem with their predictions, potentially hindering scientific advancement. To overcome this limitation, we leverage a geometric... Читать дальше...

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A multimodal Transformer Network for protein-small molecule interactions enhances predictions of kinase inhibition and enzyme-substrate relationships

by Alexander Kroll, Sahasra Ranjan, Martin J. Lercher

The activities of most enzymes and drugs depend on interactions between proteins and small molecules. Accurate prediction of these interactions could greatly accelerate pharmaceutical and biotechnological research. Current machine learning models designed for this task have a limited ability to generalize beyond the proteins used for training. This limitation is likely due to a lack of information exchange between the protein and the small... Читать дальше...