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Plos.org 

Wolbachia-induced Cytoplasmic Incompatibility drives epigenetic and maternally-influenced post-embryonic defects

by Claire Perez, Jillian Porter, Brandt Warecki, William Sullivan

A common form of Wolbachia-induced manipulation of host reproduction is Cytoplasmic Incompatibility (CI). In CI, Wolbachia modification of sperm results in pronounced defects in paternal chromosome condensation, replication, and segregation during the first mitotic division. Recent studies in D. simulans demonstrate that CI also induces independent and distinct later developmental defects resulting in high rates of mitotic... Читать дальше...

Plos.org 

Microbial fuel cells for wastewater treatment and electricity production: A multi-platform simulation workflow

by Muhammad Ali

The need for sustainable energy generation and efficient wastewater treatment continues to motivate technologies that integrate energy recovery with environmental remediation. Here, a microbial fuel cell (MFC) system is designed and evaluated, leveraging electrogenic microorganisms to produce electricity during wastewater treatment, with a focus on material selection and design configuration. The proposed design integrates key elements including a proton exchange membrane... Читать дальше...

Plos.org 

Nationwide trends and regional variation in intravitreal injections and anti-VEGF agent use in Japan from 2017 to 2022: An analysis of the NDB Open Data

by Yoshiaki Kabata, Ryo Terauchi, Tadashi Nakano

Intravitreal injections are an essential treatment modality for retinal vascular and macular diseases, yet nationwide evidence describing long-term trends, regional variation, drug composition, seasonality, and the impact of the COVID-19 pandemic in Japan remains limited. We conducted a nationwide retrospective observational study using aggregated National Database of Health Insurance Claims and Specific Health Checkups (NDB) Open Data for fiscal years (FYs) 2017–2022 (April–March). Читать дальше...