Integrating phylogenies into single-cell RNA sequencing analysis allows comparisons across species, genes, and cells
by Samuel H. Church, Jasmine L. Mah, Casey W. Dunn
Comparisons of single-cell RNA sequencing (scRNA-seq) data across species can reveal links between cellular gene expression and the evolution of cell functions, features, and phenotypes. These comparisons evoke evolutionary histories, as depicted by phylogenetic trees, that define relationships between species, genes, and cells. This Essay considers each of these in turn, laying out challenges and solutions derived from a phylogenetic comparative... Читать дальше...
