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2024

Новости за 25.06.2024

Plos.org 

The implementation of a new measles vaccine mandate in Germany: A qualitative study in local health departments

by Sophia Werdin, Julia Neufeind

Background

Measles is a highly contagious disease with the potential for severe complications. Despite the availability of effective vaccines, there have been recurrent measles outbreaks in Germany over the past decades. In response, a new measles vaccine mandate was introduced on March 1, 2020, aimed at closing vaccination gaps in high-risk populations. This study evaluates the mandate’s implementation, identifies operational challenges, assesses the impact of the Coronavirus disease 2019 pandemic... Читать дальше...

Plos.org 

Multi-objective optimization using improved NSGA-II for integrated process planning and scheduling problems in a machining job shop for large-size valve

by Junqiang Wang, Lihua Xu, Shuangqiu Sun, Yunfei Ma, Guofeng Yu

This paper studied an integrated process planning and scheduling problem from a machining workshop for large-size valves in a valve manufacturing plant. Large-size valves usually contain several key parts and are generally produced in small-series production. Almost all the parts need to be manufactured in the same workshop at the same time in the plant. Facilities have to handle various items in one order, including different models, sizes, and types. Читать дальше...

Plos.org 

Factor-GAN: Enhancing stock price prediction and factor investment with Generative Adversarial Networks

by Jiawei Wang, Zhen Chen

Deep learning, a pivotal branch of artificial intelligence, has increasingly influenced the financial domain with its advanced data processing capabilities. This paper introduces Factor-GAN, an innovative framework that utilizes Generative Adversarial Networks (GAN) technology for factor investing. Leveraging a comprehensive factor database comprising 70 firm characteristics, Factor-GAN integrates deep learning techniques with the multi-factor pricing model, thereby... Читать дальше...

Plos.org 

Orexin receptor 2 agonist activates diaphragm and genioglossus muscle through stimulating inspiratory neurons in the pre-Bötzinger complex, and phrenic and hypoglossal motoneurons in rodents

by Ryuji Yamada, Tatsuki Koike, Masanori Nakakariya, Haruhide Kimura

Orexin-mediated stimulation of orexin receptors 1/2 (OX[1/2]R) may stimulate the diaphragm and genioglossus muscle via activation of inspiratory neurons in the pre-Bötzinger complex, which are critical for the generation of inspiratory rhythm, and phrenic and hypoglossal motoneurons. Herein, we assessed the effects of OX2R-selective agonists TAK-925 (danavorexton) and OX-201 on respiratory function. In in vitro electrophysiologic analyses using rat medullary slices... Читать дальше...

Plos.org 

Early excellence and future performance advantage

by Tiantian Wang, Yaping Zhong, Xin Wei

Objectives

The objective of this study was to examine the impact of athletes achieving excellence at different ages (excellent age) on their subsequent performance development. The aim was to deepen understanding of the interplay among talent, training, and athletes’ performance development. Additionally, the study aimed to provide insights for athletics coaches to better identify talent and devise more effective personalized long-term training plans. Читать дальше...

Plos.org 

How mixed ownership affects investment efficiency? evidence from state-owned enterprises in China

by Xiaoping Huo, Yunpei Zhao, Zhihao Dong

The inefficiency observed in investment within state-owned enterprises presents a significant practical challenge that can affect the sustainable development of China’s economy. To address this issue, this study comprehensively explores the intricate mechanisms underlying the governance implications of mixed ownership on the investment efficiency of listed companies. Drawing on unbalanced panel data encompassing Shanghai and Shenzhen Stock Exchange... Читать дальше...