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Новости за 02.07.2024

Plos.org 

A deep neural network prediction method for diabetes based on Kendall’s correlation coefficient and attention mechanism

by Xiaobo Qi, Yachen Lu, Ying Shi, Hui Qi, Lifang Ren

Diabetes is a chronic disease, which is characterized by abnormally high blood sugar levels. It may affect various organs and tissues, and even lead to life-threatening complications. Accurate prediction of diabetes can significantly reduce its incidence. However, the current prediction methods struggle to accurately capture the essential characteristics of nonlinear data, and the black-box nature of these methods hampers its clinical application. Читать дальше...

Plos.org 

On traveling wave solutions with stability and phase plane analysis for the modified Benjamin-Bona-Mahony equation

by Md. Sagib, Md. Aslam Hossain, Bijan Krishna Saha, Kamruzzaman Khan

The modified Benjamin-Bona-Mahony (mBBM) model is utilized in the optical illusion field to describe the propagation of long waves in a nonlinear dispersive medium during a visual illusion (Khater 2021). This article investigates the mBBM equation through the utilization of the rational ( G ′ G )-expansion technique to derive new analytical wave solutions. The analytical solutions we have obtained comprise hyperbolic, trigonometric, and rational functions. Читать дальше...

Plos.org 

Comparison of model feature importance statistics to identify covariates that contribute most to model accuracy in prediction of insomnia

by Alexander A. Huang, Samuel Y. Huang

Importance

Sleep is critical to a person’s physical and mental health and there is a need to create high performing machine learning models and critically understand how models rank covariates.

Objective

The study aimed to compare how different model metrics rank the importance of various covariates.

Design, setting, and participants

A cross-sectional cohort study was conducted retrospectively using the National Health and Nutrition Examination Survey (NHANES)... Читать дальше...

Plos.org 

Field- and laboratory-based studies on correlates of Chlamydia trachomatis transmission by Musca sorbens: Determinants of fly-eye contact and investigations into fly carriage of elementary bodies

by Ailie Robinson, Bart Versteeg, Oumer Shafi Abdurahman, Innes Clatworthy, Gemeda Shuka, Dereje Debela, Gebreyes Hordofa, Laura Reis de Oliveira Gomes, Muluadam Abraham Aga, Gebeyehu Dumessa, Virginia Sarah, David Macleod, Anna Last, Matthew J. Burton, James G. Logan

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Plos.org 

REV3 promotes cellular tolerance to 5-fluorodeoxyuridine by activating translesion DNA synthesis and intra-S checkpoint

by Mubasshir Washif, Ryotaro Kawasumi, Kouji Hirota

The drug floxuridine (5-fluorodeoxyuridine, FUdR) is an active metabolite of 5-Fluorouracil (5-FU). It converts to 5-fluorodeoxyuridine monophosphate (FdUMP) and 5-fluorodeoxyuridine triphosphate (FdUTP), which on incorporation into the genome inhibits DNA replication. Additionally, it inhibits thymidylate synthase, causing dTMP shortage while increasing dUMP availability, which induces uracil incorporation into the genome. However, the... Читать дальше...