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Новости за 22.07.2024

Plos.org 
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Zoonotic Sporotrichosis outbreak: Emerging public health threat in the Amazon State, Brazil

by Viviany Araujo Mesquita, Sinesio Talhari, André Luiz Leturiondo, Guilherme Caldas de Souza, Euzenio Moreira de Brito, Suanni Lemos de Andrade, Débora Cristina de Lima Fernandes, Maria Zeli Moreira Frota, Rossilene Conceição da Silva Cruz, Juliana de Andrade Rebouças Guimarães, Helio Amante Miot, Carolina Talhari, Valderiza Lourenço Pedrosa

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Звезда «Сплетницы» Эд Вествик женился
У Вали Карнавал накопилось более 70 штрафов за вождение
Концерт Ланы Дель Рей оказался под угрозой срыва
Ускорьте индексацию сайта и ссылок с SpeedyIndex!
Анастасия Решетова показала, как встретила сына после отдыха. Поклонников удивила одна деталь
Умер хардкор-музыкант Джастин Чирно
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Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset

by Simon K. S. Chu, Kush Narang, Justin B. Siegel

Protein stability plays a crucial role in a variety of applications, such as food processing, therapeutics, and the identification of pathogenic mutations. Engineering campaigns commonly seek to improve protein stability, and there is a strong interest in streamlining these processes to enable rapid optimization of highly stabilized proteins with fewer iterations. In this work, we explore utilizing a mega-scale dataset to develop a protein... Читать дальше...

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Simulation of Soluble and Bound VEGF-stimulated in vitro Capillary-like Network Formation on Deformed Substrate

by Hsun Chiang, Chih-Ang Chung

Capillary plexus cultivation is crucial in tissue engineering and regenerative medicine. Theoretical simulations have been conducted to supplement the expensive experimental works. However, the mechanisms connecting mechanical and chemical stimuli remained undefined, and the functions of the different VEGF forms in the culture environment were still unclear. In this paper, we developed a hybrid model for simulating short-term in vitro capillary incubations.... Читать дальше...

Athletics Nation 
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Elephant Rumblings: Saying goodbye to the Coliseum

Kelley L Cox-USA TODAY Sports

MLB news roundup

Happy Monday, Athletics Nation!

I was driving back to LA on the I-5 yesterday when the A’s bid for a second straight sweep of the Angels abruptly fell apart in the eighth inning. It was a disappointing finish to a successful series that the A’s won with refreshingly consistent offensive production.

I was at Saturday’s game, which unfortunately I believe was my last at the Coliseum. It was a terrific experience. My friends... Читать дальше...

Праздничные богослужения пройдут в Печорах к Успению Пресвятой Богородицы,
"Этой стране конец!" В Сети подняли тревогу из-за задержания Дурова. Грядет глобальный скандал?
Рассвет на озере
Солнечная погода будет преобладать на Северо-Западе в последнюю неделю лета
Забег в костюмах героев мультфильмов организуют в Пскове
Сбывается "худший кошмар" Демпартии США: Трамп получил неожиданную поддержку и готов мстить
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Endurance training volume cannot entirely substitute for the lack of intensity

by Pekka Matomäki, Olli J. Heinonen, Ari Nummela, Heikki Kyröläinen

Purpose

Very low intensity endurance training (LIT) does not seem to improve maximal oxygen uptake. The purpose of the present study was to investigate if very high volume of LIT could compensate the lack of intensity and is LIT affecting differently low and high intensity performances.

Methods

Recreationally active untrained participants (n = 35; 21 females) cycled either LIT (mean training time 6.7 ± 0.7 h / week at 63% of maximal heart rate... Читать дальше...

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Role of social media to improve job performance with mediating role of transactive memory capability and employee creativity

by Jingyu Fu

The increased usage of social media in organizational settings has raised questions about its effect on job performance. This study explains the interplay between social media usage, transactive memory capability, employee creativity, and job performance within the Chinese organizational context. The rationale for this study stems from the need to understand how social media usage can enhance job performance through cognitive and creative processes within teams. On the basis of earlier literature... Читать дальше...

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Relationship between protein conformational stability and its immunogenicity when administering antigens to mice using adjuvants—Analysis employed the CH2 domain in human antibodies

by Kosuke Oyama, Tadashi Ueda

Antigen-presenting cells (APCs) play a crucial role in the immune system by breaking down antigens into peptide fragments that subsequently bind to major histocompatibility complex (MHC) molecules. Previous studies indicate that stable proteins can impede CD4+ T cell stimulation by hindering antigen processing and presentation. Conversely, certain proteins require stabilization in order to activate the immune response. Several factors, including the characteristics... Читать дальше...