by Todd A. Surovell, Sarah A. Allaun, Barbara A. Crass, Joseph A. M. Gingerich, Kelly E. Graf, Charles E. Holmes, Robert L. Kelly, Marcel Kornfeld, Kathryn E. Krasinski, Mary Lou Larson, Spencer R. Pelton, Brian T. Wygal
by Jinat Alam, Md. Ridwan Islam, Shah Mohammad Fahim, Md. Amran Gazi, Tahmeed Ahmed
by Ahmed N. Balshi, Mohammed A. Al-Odat, Abdulrahman M. Alharthy, Rayan A. Alshaya, Hanan M. Alenzi, Alhadzia S. Dambung, Huda Mhawish, Saad M. Altamimi, Waleed Th. Aletreby
by Tom H. Oreel, Pythia T. Nieuwkerk, Iris D. Hartog, Justine E. Netjes, Alexander B. A. Vonk, Jorrit Lemkes, Hanneke W. M. van Laarhoven, Michael Scherer-Rath, Mirjam A. G. Sprangers, José P. S. Henriques
by Xing Guo, Run Zhang, Juan Liu, Min Li, Chunhua Song, Sinisa Dovat, Jianyong Li, Zheng Ge
by Wentao Li, Han Chen, Xiaoqian Jiang, Arif Harmanci
Increasing genetic and phenotypic data size is critical for understanding the genetic determinants of diseases. Evidently, establishing practical means for collaboration and data sharing among institutions is a fundamental methodological barrier for performing high-powered studies. As the sample sizes become more heterogeneous, complex statistical approaches, such as generalized linear mixed effects models, must be used to correct for the confounders that may bias results. Читать дальше...
by Pierre Le Denmat, Tom Verguts, Kobe Desender
Human decision making is accompanied by a sense of confidence. According to Bayesian decision theory, confidence reflects the learned probability of making a correct response, given available data (e.g., accumulated stimulus evidence and response time). Although optimal, independently learning these probabilities for all possible data combinations is computationally intractable. Here, we describe a novel model of confidence implementing a low-dimensional... Читать дальше...
by Virgile Andreani, Eric J. South, Mary J. Dunlop
Dense arrangements of binding sites within nucleotide sequences can collectively influence downstream transcription rates or initiate biomolecular interactions. For example, natural promoter regions can harbor many overlapping transcription factor binding sites that influence the rate of transcription initiation. Despite the prevalence of overlapping binding sites in nature, rapid design of nucleotide sequences with many overlapping sites remains a challenge. Читать дальше...
by Noah B. Herrington, Yan Chak Li, David Stein, Gaurav Pandey, Avner Schlessinger
Читать дальше...
by Ben Ewen-Campen, Norbert Perrimon
Despite the deep conservation of the DNA damage response (DDR) pathway, cells in different contexts vary widely in their susceptibility to DNA damage and their propensity to undergo apoptosis as a result of genomic lesions. One of the cell signaling pathways implicated in modulating the DDR is the highly conserved Wnt pathway, which is known to promote resistance to DNA damage caused by ionizing radiation in a variety of human cancers. However, the mechanisms... Читать дальше...
It’s been a long, winding road through the Land of Women for Gala and her family. And the adventure has …
Читать дальше...
Apple TV+ is ready to let Bad Monkey out of its cage. Three years after the Vince Vaughn vehicle was handed a series order, Bad Monkey will see the light of day when its first two episodes arrive on Aug. 14. New episodes will then follow every Wednesday, through Oct. 9. Based on Carl Hiaasen’s […]
Kevin Jairaj-USA TODAY Sports
The Mariners made their top two draft signings official.
Читать дальше...
Stan Szeto-USA TODAY Sports
MLB news roundup
Happy Wednesday, Athletics Nation!
The Astros came to Oakland this week with a 6-1 advantage in the season series between the two teams, but the A’s have been exacting sweet revenge over the past two games of the current series at the Coliseum as Lawrence Butler, Brent Rooker, and JJ Bleday continue to swing hot bats for an Oakland club that has been among baseball’s best offensive teams in July.
Back in May, the Astros... Читать дальше...
Photo by Zac BonDurant/MLB Photos via Getty Images
Sometimes valuable big leaguers come from places you’d least expect.
Читать дальше...
Cleveland Guardians minor league recap for Wednesday, July 24, 2024
Columbus Clippers 8, Memphis Redbirds 6
Box Score · Clippers improve to 45-50
This was the Johnathan Rodriguez show. The slugging right fielder went 4-for-4 at the dish with two runs batted in and three runs scored.
#Guardians 24yr old OF prospect Johnathan Rodriguez with a 4-hit day today (4-4 3R 2RBI) for Columbus driving in a pair of runs in his teams 8-to-6 win over Memphis.
Rodriguez is... Читать дальше...
Sustainability leaders have started using AI for energy efficiency improvements, carbon emissions modeling and compliance with regulations.
After making her professional debut in 2018, Leylah Annie Fernandez has been climbing the ranks and since 2021, she has...
For most Team Canada fans, Maggie Mac Neil needs no introduction. The 24-year-old is a powerhouse in the pool, bringing...
This week, the City of Lights is the City of Flights. Let the games begin!
The lineup highlights first-time features and sophomore films from emerging international filmmakers, like "Bonjour Tristesse" director Durga Chew-Bose.
The "Scrubs" creator and "Ted Lasso" producer is the showrunner and executive producer of the adaptation of Carl Hiaasen's bestselling novel.
From ceremony dancers to airport staff—a number of labor disputes in the French capital could cast a shadow over the Summer Games.
Amid softer EV demand and worsening profit margins this year, Tesla is setting its sights on AI as Elon Musk is betting more on self-driving and artificial intelligence. The AI hype has investors hooked in the past three months since Tesla’s underwhelming first-quarter deliveries and earnings numbers published in April. The company’s value has risen by $386 billion since then, per Bloomberg’s estimates, as Musk has been touting a Tesla future of AI, autonomous driving, and humanoid robots…
