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2024

Новости за 22.08.2024

Plos.org 

Tamsulosin use in benign prostatic hyperplasia and risks of Parkinson’s disease, Alzheimer’s disease and mortality: An observational cohort study of elderly Medicare enrollees

by Kin Wah Fung, Fitsum Baye, Seo H. Baik, Clement J. McDonald

Purpose

To study the effects of benign prostatic hyperplasia treatments, namely: alpha-adrenergic receptor blockers, 5-alpha-reductase inhibitors and phosphodiesterase-5 inhibitors on the risk of Parkinson’s disease, Alzheimer’s disease and mortality.

Materials and methods

All male Medicare enrollees aged 65 or above who were diagnosed with benign prostatic hyperplasia and received one of the study drugs between 2007–2020 were followed-up for the three outcomes. Читать дальше...

Plos.org 

A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans

by Shaonil Binti, Adison G. Linder, Philip T. Edeen, David S. Fay

Protein tyrosine phosphatases non-receptor type (PTPNs) have been studied extensively in the context of the adaptive immune system; however, their roles beyond immunoregulation are less well explored. Here we identify novel functions for the conserved C. elegans phosphatase PTPN-22, establishing its role in nematode molting, cell adhesion, and cytoskeletal regulation. Through a non-biased genetic screen, we found that loss... Читать дальше...