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Новости за 03.09.2024

Plos.org 
En

Structural insight into the DNMT1 reaction cycle by cryo-electron microscopy

by Inessa De, Jonas Weidenhausen, Nestor Concha, Christoph W. Müller

DNMT1 is an essential DNA methyltransferase that catalyzes the transfer of methyl groups to CpG islands in DNA and generates a prominent epigenetic mark. The catalytic activity of DNMT1 relies on its conformational plasticity and ability to change conformation from an auto-inhibited to an activated state. Here, we present four cryo-EM reconstructions of apo DNMT1 and DNTM1: non-productive DNA, DNTM1: H3Ub2-peptide, DNTM1: productive DNA complexes. Читать дальше...

Скромно плелась сзади: редкий выход Собчак с мужем привлек внимание
Гвинет Пэлтроу и Риз Уизерспун показали летнее фото в купальниках
Бренд SERGINNETTI представляет новую коллекцию Осень 2024
Никита Кологривый, Анастасия Решетова, Алена Апина и другие на премьере сериала «Комбинация»
Дэниел Крейг вышел на красную дорожку Венецианского кинофестиваля вместе с женой Рэйчел Вайс
Сальма Хайек поделилась горячими снимками в честь своего дня рождения
Plos.org 
En

Assessment of photodynamic therapy with annatto and led for the treatment of halitosis in mouth-breathing children: Randomized controlled clinical trial

by Laura Hermida Bruno, Amanda Rafaelly Honório Mandetta, Ana Paula Taboada Sobral, Marcela Leticia Leal Gonçalves, Elaine Marcilio Santos, Ana Laura Fossati, Juliana Maria Altavista Sagretti Gallo, Pamella de Barros Motta, Alessandro Melo Deana, Anna Carolina Ratto Tempestini Horliana, Lara Jansiski Motta, Raquel Agnelli Mesquita Ferrari, Kristianne Porta Santos Fernandes, Sandra Kalil Bussadori

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Plos.org 
En

Alpha-boswellic acid accelerates acute wound healing via NF-κB signaling pathway

by Fang Dong, Lijuan Zheng, Xuanfen Zhang

Background

Boswellic acids (BAs) showed promising effects in cancer treatment, immune response regulation, and anti-inflammatory therapy. We aimed to assess the roles of alpha-BA (α-BA) in treating acute wound healing.

Methods

In vivo wound-healing models were established to evaluate the therapeutic effects of α-BA. Cell assays were conducted to assess the impact of α-BA on cellular biological functions. Western blot analysis was employed... Читать дальше...

Plos.org 
En

Asymmetric dynamic linkage between consumer sentiment, inflation expectations, and international energy prices: Evidence from time-frequency wavelet and nonlinear analysis

by Lianlian Fu, Dongyu Yuan, Jiamin Teng

This study investigates the relationship between consumer sentiment (CONS), inflation expectations (INEX) and international energy prices, drawing on principles from behavioral. We focus on Brent crude oil price and Henry Hub natural gas prices as key indicators of energy market dynamics. Based on the monthly data from January 2003 to March 2023, three wavelet methods are applied to examine the time-frequency linkage, while the nonlinear distributed... Читать дальше...

Plos.org 
En

The temporal distribution of ridership in metro stations from land-use perspective

by Shian Dai, Liqiang Yu, Lang Song, Ying Li, Xuze Fan

A reasonable land use development around subway stations can balance the utilization rates of the subway system during peak and off-peak hours, thereby enhancing its service levels and operational efficiency. Analyzing the temporal distribution patterns of passenger flow and their influencing factors is crucial for determining the optimum ratio of each land use type surrounding metro stations. Thus, this paper employs principal component... Читать дальше...

Plos.org 
En

Investigating the association between household exposure to Anopheles stephensi and malaria in Sudan and Ethiopia: A case-control study protocol

by Temesgen Ashine, Yehenew Asmamaw Ebstie, Rayyan Ibrahim, Adrienne Epstein, John Bradley, Mujahid Nouredayem, Mikiyas G. Michael, Amani Sidiahmed, Nigatu Negash, Abena Kochora, Jihad Eltaher Sulieman, Alison M. Reynolds, Eba Alemayehu, Endalew Zemene, Adane Eyasu, Alemayehu Dagne, Elifaged Hailemeskel, Fatou Jaiteh, Dereje Geleta, Ephrem Lejore, David Weetman, Ahmed Mahmoud Hussien, Fadwa Saad, Gudissa Assefa, Hiwot Solomon, Abdelgadir Bashir, Fekadu Massebo, Koen Peeters, Delenasaw Yewhalaw, Hmooda Toto Kafy, Martin J. Читать дальше...

Plos.org 
En

Cognitive stimulation in activities of daily living for individuals with mild-to-moderate dementia (CS-ADL): Study protocol for a randomised controlled trial

by Simone M. Ryan, Orla Brady

Background

Multi-component CS programs incorporating practice of activities of daily living (ADL) into intervention have reported benefits for ADL outcomes in individuals living with mild-to-moderate dementia. A randomised controlled trial (RCT) within community occupational therapy services in Ireland, is planned to evaluate the effects of CS-ADL, an ADL-focused, multi-component CS program, on ADL outcomes for individuals living with mild-to-moderate dementia. Читать дальше...

В Пскове пройдет шоукейс для музыкантов «За музыкой»
Храм, музей, мемориал и спортивный центр посетил в ходе рабочей поездки в Гдовский район Александр Котов
С вопросами о личной жизни во время собеседования столкнулись 75% псковичей – опрос
«Пять одноклассников у меня не вернулись домой» // В Беслане закончилась траурная вахта памяти
«Ахмат» вернул недавно забытое старое // Команда объявила о возвращении главного тренера Сергея Ташуева
Новостройки уходят в минус // Выполнение нацпроекта по жилью оказалось под угрозой
Plos.org 
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Identify the digitalization technology opportunity of low-carbon energy technologies: Using the patent data and collaborative filtering

by Jie Liu, Wanlin Cai

The digitalization of low-carbon energy technologies (LCET) provides important technical support for the transition to a greener energy system. Digitalization addresses the phenomenon of the growing application of information and communications technologies (ICT) across the economy, which is regarded as the technology convergence between ICT and other technologies. Scholars have revealed the signs that LCET and ICT are becoming increasingly interlinked, which raises... Читать дальше...

Plos.org 
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Low dose TamOxifen and LifestylE changes for bReast cANcer prevention (TOLERANT study): Study protocol of a randomized phase II biomarker trial in women at increased risk for breast cancer

by Aliana Guerrieri-Gonzaga, Davide Serrano, Patrizia Gnagnarella, Harriet Johansson, Stefania Zovato, Mariateresa Nardi, Matilde Pensabene, Simona Buccolo, Andrea DeCensi, Irene Maria Briata, Luigi Pistelli, Clementina Sansone, Sara Mannucci, Valentina Aristarco, Debora Macis, Matteo Lazzeroni, Gaetano Aurilio, Chiara Arianna Accornero, Sara Gandini, Bernardo Bonanni

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Plos.org 
En

Impact of music learning on students’ psychological development with mediating role of self-efficacy and self-esteem

by Jing Jiang

Professionals and academics have recently placed a greater emphasis on comprehending the elements that go into improving students’ psychological wellbeing. Students frequently face major obstacles as a result of the rigorous nature of academic life, which can result in problems like tension, depression and other psychological health concerns. These complications have a long-lasting influence on their future aspirations in addition to affecting their academic achievement. This... Читать дальше...

Plos.org 
En

A navigational risk evaluation of ferry transport: Continuous risk management matrix based on fuzzy Best-Worst Method

by Linh Thi Pham, Long Van Hoang

Ferry transport has witnessed numerous fatal accidents due to unsafe navigation; thus, it is of paramount importance to mitigate risks and enhance safety measures in ferry navigation. This paper aims to evaluate the navigational risk of ferry transport by a continuous risk management matrix (CRMM) based on the fuzzy Best-Worst Method (BMW). Its originalities include developing CRMM to figure out the risk level of risk factors (RFs) for ferry transport and... Читать дальше...