by Jordan Jennings, Harrison Bracey, Jun Hong, Danny T. Nguyen, Rishav Dasgupta, Alondra Vázquez Rivera, Nicolas Sluis-Cremer, Jiong Shi, Christopher Aiken
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by Derek J. Taylor, Max H. Barnhart
Although several filoviruses are dangerous human pathogens, there is conflicting evidence regarding their origins and interactions with animal hosts. Here we attempt to improve this understanding using the paleoviral record over a geological time scale, protein structure predictions, tests for evolutionary maintenance, and phylogenetic methods that alleviate sources of bias and error. We found evidence for long branch attraction bias in the L gene tree for filoviruses... Читать дальше...
by Wei Wang, Ali Pope, Ella Ward-Shaw, Darya Buehler, Francoise Bachelerie, Paul F. Lambert
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by Kening Wang, Tristan Jordan, Kennichi Dowdell, Richard Herbert, Ian N. Moore, David M. Koelle, Jeffrey I. Cohen
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by Turgut E. Aktepe, Joshua M. Deerain, Jennifer L. Hyde, Svenja Fritzlar, Eleanor M. Mead, Julio Carrera Montoya, Abderrahman Hachani, Jaclyn S. Pearson, Peter A. White, Jason M. Mackenzie
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by Xi Luo, Litian Zhang, Xiaoyuan Xie, Liyan Yuan, Yanqiang Shi, Yinbo Jiang, Wujian Ke, Bin Yang
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by Inessa De, Jonas Weidenhausen, Nestor Concha, Christoph W. Müller
DNMT1 is an essential DNA methyltransferase that catalyzes the transfer of methyl groups to CpG islands in DNA and generates a prominent epigenetic mark. The catalytic activity of DNMT1 relies on its conformational plasticity and ability to change conformation from an auto-inhibited to an activated state. Here, we present four cryo-EM reconstructions of apo DNMT1 and DNTM1: non-productive DNA, DNTM1: H3Ub2-peptide, DNTM1: productive DNA complexes. Читать дальше...
by Ali Sepehrinezhad, Negin Ghiyasi Moghaddam, Navidreza Shayan, Sajad Sahab Negah
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by Kenny Nguyen, Boris Relja, Monica Epperson, So Hee Park, Natalie J. Thornburg, Veronica P. Costantini, Jan Vinjé
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by Laura Hermida Bruno, Amanda Rafaelly Honório Mandetta, Ana Paula Taboada Sobral, Marcela Leticia Leal Gonçalves, Elaine Marcilio Santos, Ana Laura Fossati, Juliana Maria Altavista Sagretti Gallo, Pamella de Barros Motta, Alessandro Melo Deana, Anna Carolina Ratto Tempestini Horliana, Lara Jansiski Motta, Raquel Agnelli Mesquita Ferrari, Kristianne Porta Santos Fernandes, Sandra Kalil Bussadori
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by Fang Dong, Lijuan Zheng, Xuanfen Zhang
BackgroundBoswellic acids (BAs) showed promising effects in cancer treatment, immune response regulation, and anti-inflammatory therapy. We aimed to assess the roles of alpha-BA (α-BA) in treating acute wound healing.
MethodsIn vivo wound-healing models were established to evaluate the therapeutic effects of α-BA. Cell assays were conducted to assess the impact of α-BA on cellular biological functions. Western blot analysis was employed... Читать дальше...
by Liss Marita Solbakken, Antje Sundseth, Birgitta Langhammer, Therese Brovold
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by Xuehua Zhan, Wenqi Yuan, Rong Ma, Yueyong Zhou, Guangxian Xu, Zhaohui Ge
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by Lianlian Fu, Dongyu Yuan, Jiamin Teng
This study investigates the relationship between consumer sentiment (CONS), inflation expectations (INEX) and international energy prices, drawing on principles from behavioral. We focus on Brent crude oil price and Henry Hub natural gas prices as key indicators of energy market dynamics. Based on the monthly data from January 2003 to March 2023, three wavelet methods are applied to examine the time-frequency linkage, while the nonlinear distributed... Читать дальше...
by Abishek Arora, Francesca Mastropasqua, Sven Bölte, Kristiina Tammimies
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by Matti Viluksela, Pertti Saurola, Juhani Koivusaari, Matts Finnlund, Anders Bignert, Riikka Airaksinen, Päivi Ruokojärvi, Matti Verta, Hannu Kiviranta, Jouni T. Tuomisto, Panu Rantakokko
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by Shian Dai, Liqiang Yu, Lang Song, Ying Li, Xuze Fan
A reasonable land use development around subway stations can balance the utilization rates of the subway system during peak and off-peak hours, thereby enhancing its service levels and operational efficiency. Analyzing the temporal distribution patterns of passenger flow and their influencing factors is crucial for determining the optimum ratio of each land use type surrounding metro stations. Thus, this paper employs principal component... Читать дальше...
by Temesgen Ashine, Yehenew Asmamaw Ebstie, Rayyan Ibrahim, Adrienne Epstein, John Bradley, Mujahid Nouredayem, Mikiyas G. Michael, Amani Sidiahmed, Nigatu Negash, Abena Kochora, Jihad Eltaher Sulieman, Alison M. Reynolds, Eba Alemayehu, Endalew Zemene, Adane Eyasu, Alemayehu Dagne, Elifaged Hailemeskel, Fatou Jaiteh, Dereje Geleta, Ephrem Lejore, David Weetman, Ahmed Mahmoud Hussien, Fadwa Saad, Gudissa Assefa, Hiwot Solomon, Abdelgadir Bashir, Fekadu Massebo, Koen Peeters, Delenasaw Yewhalaw, Hmooda Toto Kafy, Martin J. Читать дальше...
by Simone M. Ryan, Orla Brady
BackgroundMulti-component CS programs incorporating practice of activities of daily living (ADL) into intervention have reported benefits for ADL outcomes in individuals living with mild-to-moderate dementia. A randomised controlled trial (RCT) within community occupational therapy services in Ireland, is planned to evaluate the effects of CS-ADL, an ADL-focused, multi-component CS program, on ADL outcomes for individuals living with mild-to-moderate dementia. Читать дальше...
by Christina Potter, Rachel Pechey, Michael Clark, Kerstin Frie, Paul A. Bateman, Brian Cook, Cristina Stewart, Carmen Piernas, John Lynch, Mike Rayner, Joseph Poore, Susan A. Jebb
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by Silvia Pérez-Piñero, Domingo Jesús Ramos-Campo, Francisco Javier López-Román, Raquel Ortolano, Antonio Torregrosa-García, Antonio Jesús Luque-Rubia, Natalia Ibáñez-Soroa, Luis Andreu-Caravaca, Vicente Ávila-Gandía
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by Jie Liu, Wanlin Cai
The digitalization of low-carbon energy technologies (LCET) provides important technical support for the transition to a greener energy system. Digitalization addresses the phenomenon of the growing application of information and communications technologies (ICT) across the economy, which is regarded as the technology convergence between ICT and other technologies. Scholars have revealed the signs that LCET and ICT are becoming increasingly interlinked, which raises... Читать дальше...
by Geoffroy Byanpambé, Philippe Djondiné, Golam Guidkaya, Mohammed F. Elnaggar, Alexis Paldou Yaya, Emmanuel Tchindebé, Kitmo, Noel Djongyang
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by Aliana Guerrieri-Gonzaga, Davide Serrano, Patrizia Gnagnarella, Harriet Johansson, Stefania Zovato, Mariateresa Nardi, Matilde Pensabene, Simona Buccolo, Andrea DeCensi, Irene Maria Briata, Luigi Pistelli, Clementina Sansone, Sara Mannucci, Valentina Aristarco, Debora Macis, Matteo Lazzeroni, Gaetano Aurilio, Chiara Arianna Accornero, Sara Gandini, Bernardo Bonanni
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by Juan Marcos Gonzalez Sepulveda, Michael Townsend, Heidi C. Waters, Maalak Brubaker, Matthew Wallace, Reed Johnson
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