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2024
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Новости за 15.10.2024

Plos.org 
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Do morphogenetic switching and intraspecies variation enhance virulence of Candida auris?

by Trinh Phan-Canh, Karl Kuchler

Intraspecies variations that affect pathogenicity and antifungal resistance traits pose a serious obstacle to efficient therapy of Candida auris infections. Recent reports indicate that mutations determine drug susceptibility and virulence. However, mutations alone cannot fully explain a bewildering variety of phenotypes in clinical isolates from known C. auris clades, suggesting an unprecedented complexity underlying virulence traits and antifungal resistance. Читать дальше...

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Discovery, recognized antigenic structures, and evolution of cross-serotype broadly neutralizing antibodies from porcine B-cell repertoires against foot-and-mouth disease virus

by Fengjuan Li, Shanquan Wu, Lv Lv, Shulun Huang, Zelin Zhang, Zhaxi Zerang, Pinghua Li, Yimei Cao, Huifang Bao, Pu Sun, Xingwen Bai, Yong He, Yuanfang Fu, Hong Yuan, Xueqing Ma, Zhixun Zhao, Jing Zhang, Jian Wang, Tao Wang, Dong Li, Qiang Zhang, Jijun He, Zaixin Liu, Zengjun Lu, Dongsheng Lei, Kun Li

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Characterisation of the antibody-mediated selective pressure driving intra-host evolution of SARS-CoV-2 in prolonged infection

by Michael Schoefbaenker, Theresa Günther, Eva Ulla Lorentzen, Marie-Luise Romberg, Marc Tim Hennies, Rieke Neddermeyer, Marlin Maybrit Müller, Alexander Mellmann, Chiara Robin Bojarzyn, Georg Lenz, Matthias Stelljes, Eike Roman Hrincius, Richard Vollenberg, Stephan Ludwig, Phil-Robin Tepasse, Joachim Ewald Kühn

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Снег, метель и дома без света: Вильфанд предупредил о последствиях аномально теплой зимы
«Эксмо» убрало из продажи книгу Тилар Маццео о спасении детей из гетто
Ким Кардашьян раскритиковали за рекламу SKIMS на фоне пожаров в Лос-Анджелесе
Ваш час настал: Вселенная готова финансово помочь 2 знакам
Винит себя в смерти возлюбленной и везде опаздывает: неизвестные факты из жизни Андрея Малахова
Празднуем Старый Новый год по-гречески!
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Path of career planning and employment strategy based on deep learning in the information age

by Yichi Zhang

With the improvement of education level and the expansion of higher education, more students can have the opportunities to obtain better education, and the pressure of employment competition is also increasing. How to improve students’ employment competitiveness, comprehensive quality and the ability to explore paths for career planning and employment strategies has become a common concern in today’s society. Under the background of today’s informatization, the paths of career... Читать дальше...

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Dosimetry model for photobiomodulation based on anthropometric and hemodynamic variables in patients with orofacial pain post-Covid-19: Study protocol for randomized clinical trial

by Silvana Simões Velloso Schuler, Mayra Costanti Vilela Campos, Ana Julia Lacerda, Adriana Cátia Mazzoni, Tamiris Silva, Francine Cristina da Silva, Manoela Domingues Martins, Kristianne Porta Santos Fernandes, Elsa Susana Fonseca, Raquel Agnelli Mesquita-Ferrari, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Lara Jansiski Motta

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Association between blood total mercury and psoriasis: The NHANES 2005–2006 and 2013–2014: A cross-sectional study

by Yanan Tuo, Yali Li, Tao Guo

An inflammatory skin condition called psoriasis results from immune system interactions that are out of balance. Reactive oxygen species are produced as a general mechanism of mercury toxicity. This study aimed to determine whether there was an association between blood total mercury and psoriasis in US adults. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2005–2006 and 2013–2014. NHANES is a national research survey program... Читать дальше...

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Risk factors for postoperative acute kidney injury after radical cystectomy for bladder cancer in the era of ERAS protocols: A retrospective observational study

by Mathieu Marques, Marie Tezier, Maxime Tourret, Laure Cazenave, Clément Brun, Lam Nguyen Duong, Sylvie Cambon, Camille Pouliquen, Florence Ettori, Antoine Sannini, Frédéric Gonzalez, Magali Bisbal, Laurent Chow-Chine, Luca Servan, Jean Manuel de Guibert, Marion Faucher, Djamel Mokart

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Efficacy of wooden toy training in alleviating cognitive decline in elderly individuals with cognitive impairment: A cluster randomized controlled study

by Qiuping Cheng, Hanqian Wang, Mengni Cui, Qunlong Wang, Lu Li

Background

With the increasing global aging population, the health and welfare of elderly individuals, especially individuals with prevalent mild cognitive impairment (MCI) living in nursing homes, have become critical concerns. These concerns highlight the urgency of developing effective interventions to address the cognitive and psychological needs of elderly individuals, ensuring their well-being and alleviating the burden on their caregivers. Читать дальше...

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The research of knowledge diffusion network model for Tourism Destination-Public ecological civilization

by Jiehua Xu, Peng Peng, Dongping Wei, Zhijun Deng

Visitor education plays a crucial role in the knowledge diffusion process in outdoor recreation and nature-based tourism. It entails sharing information, experiences, and insights with visitors to enhance their understanding and appreciation of the natural environment. Our methodology for investigating the diffusion of ecological civilization knowledge in tourism destinations involves constructing a knowledge diffusion network model. In this model... Читать дальше...

Движение по Рижскому проспекту в Пскове затруднено из-за ДТП с автобусом
Праздничный концерт «Старый Новый год на пороге» пройдёт в ТРЦ «Нора»
Уборка дома с клининговой компанией КлинОн
Отчётный концерт клуба «Колибри»
Семиместный кроссовер Chery Tiggo 8 PRO MAX
Налипание мокрого снега ожидается на территории Псковской области
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How much is too much: A case study of local self-government units in Slovakia using absolute variability to determine the importance of financial criteria in MCDM analysis

by Roman Vavrek

The performance evaluation of local self-government entities is very difficult, as their primary goal is not to make a profit, but to provide services to their residents that will contribute to an increase in their quality of life. In this context, it is necessary to evaluate their activity from the point of view of several available criteria, for which it is possible to find relevant and recognized sources. The presented research works with five criteria, identified by the Institute for Economic and Social Reforms... Читать дальше...

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Simultaneous confidence interval construction for many-to-one of proportion ratios of bilateral correlated data

by Zhaoqi Zhang, Chang-Xing Ma

In ophthalmology and otolaryngology, data collected from paired body parts are typically reformatted into categorical bilateral data structures for subsequent research. This article applies Donner’s equal correlation coefficient model and obtains nine simultaneous confidence intervals (SCI) of proportion ratios under three asymptotic statistical methods and three ways of multiplicity adjustment. The empirical coverage probability and mean interval width are evaluated through Monte Carlo simulations. Читать дальше...

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Neighborhood poverty and hopelessness in older adults: The mediating role of perceived neighborhood disorder

by Yeon Jin Choi, Eun Young Choi, Jennifer A. Ailshire

Hopelessness is one of the strongest predictors of health and mortality, particularly for older populations. Prior research has found associations between individual-level socioeconomic factors and hopelessness, but less is known about the potential importance of neighborhood-level socioeconomic contexts for hopelessness. In particular, the role of neighborhood disorder as a potential explanatory factor for poor psychological well-being remains underexplored. Читать дальше...

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Prediabetes increases the risk of pancreatic cancer: A meta-analysis of longitudinal observational studies

by Xuefang Huang, Huan Li, Lisha Zhao, Lingli Xu, Hui Long

Background

Glycemic disorder is closely related to the risk of pancreatic cancer, but previous studies focused on the influence of diabetes. The aim of this meta-analysis was to investigate the influence of prediabetes, an intermediate state between normoglycemia and diabetes, on the risk of pancreatic cancer.

Methods

Relevant longitudinal observational studies were identified through a search of Medline, Embase, and Web of Science databases. Читать дальше...