by Masoumeh Beig, Elaheh Ebrahimi, Safoura Moradkasani, Forough Goodarzi, Mohammad Sholeh, Narges Golab
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by Asheley R. Landrum, Dominik A. Stecuła, Matthew Motta
Climate-facilitated spread of mosquito-borne pathogens to new environments elevates the importance of policies that limit greenhouse gas emissions as well as the development and uptake of new pharmaceutical interventions. Whereas past research attempts to bolster support for both through either climate or health risk communication, fewer attempt to combine the risks borne by climate change and infectious disease with a single messaging intervention... Читать дальше...
by Chiara Cássia Oliveira Amorim, Denise Silva Nogueira, Ana Clara Gazzinelli-Guimarães, Thais Leal Silva, Fernando Sérgio Barbosa, Fabrício Marcus Silva Oliveira, Lucas Rocha Kraemer, Raquel Martins de Almeida, Jorge Lucas Nascimento Souza, Luisa Mourão Dias Magalhães, Remo Castro Russo, Marcelo Vidigal Caliari, Soraya Gaze, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara
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by Nalini Kaushalya Jayakody, Anjana Silva, Susiji Wickramasinghe, Nilanthi de Silva, Sisira Siribaddana, Kosala Gayan Weerakoon
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by Suélen Fernandes Silva, Angélica Hollunder Klippel, Sunniva Sigurdardóttir, Sayyed Jalil Mahdizadeh, Ievgeniia Tiukova, Catarina Bourgard, Luis Carlos Salazar-Alvarez, Heloísa Monteiro do Amaral Prado, Renan Vinicius de Araujo, Fabio Trindade Maranhão Costa, Elizabeth Bilsland, Ross D. King, Katlin Brauer Massirer, Leif A. Eriksson, Mário Henrique Bengtson, Cleslei Fernando Zanelli, Per Sunnerhagen
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by Yuhao Zhao, Yajuan Wang, Yi Li, Chao Song, Pinhua Pan
BackgroundNext-generation sequencing (NGS) is a promising diagnostic tool for pathogens diagnosis. The aim of this study is to evaluate the application of NGS-based antimicrobial therapy on clinical outcomes in severe community-acquired pneumonia (SCAP) patients with empiric antimicrobial therapy failure.
MethodologyWe performed a multi-center, retrospective cohort of SCAP patients with initial empiric therapy failure. Propensity... Читать дальше...
by Mehmet Can Ulucesme, Sezayi Ozubek, Munir Aktas
Small ruminant babesiosis remains a neglected disease despite causing significant economic losses to sheep and goat herds in many regions around the world. The pathogenesis and clinical manifestations of ovine babesiosis are well-known, but there is a lack of information regarding caprine babesiosis. Since the discovery of the first Babesia spp. in 1888, several species/subspecies/genotypes, including Babesia aktasi, have been described.... Читать дальше...
by Camila Bonfim, Flávia Alves, Érika Fialho, John A. Naslund, Maurício L. Barreto, Vikram Patel, Daiane Borges Machado
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by Matthew R. Dunn, Didong Li, Marc A. Emerson, Caroline A. Thompson, Hazel B. Nichols, Sarah C. Van Alsten, Mya L. Roberson, Stephanie B. Wheeler, Lisa A. Carey, Terry Hyslop, Jennifer Elston Lafata, Melissa A. Troester
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by Asad Hasan, Michael C. Whitlock
Background selection, by which selection on deleterious alleles reduces diversity at linked neutral sites, influences patterns of total neutral diversity, πT, and genetic differentiation, FST, in structured populations. The theory of background selection may be split into two regimes: the background selection regime, where selection pressures are strong and mutation rates are sufficiently low such that deleterious alleles are at a deterministic mutation-selection balance... Читать дальше...
by Jeffrey P. Sagun, Sikandar G. Khan, Kyoko Imoto, Deborah Tamura, Kyu-Seon Oh, John J. DiGiovanna, Kenneth H. Kraemer
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by Martin Sztacho, Jakub Červenka, Barbora Šalovská, Ludovica Antiga, Peter Hoboth, Pavel Hozák
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by Haihan Zhang, Kevin He, Zheng Li, Lam C. Tsoi, Xiang Zhou
Transcriptome-wide association studies (TWAS) have emerged as a powerful tool for identifying gene-trait associations by integrating gene expression mapping studies with genome-wide association studies (GWAS). While most existing TWAS approaches focus on marginal analyses through examining one gene at a time, recent developments in TWAS fine-mapping methods enable the joint modeling of multiple genes to refine the identification of potentially causal ones. Читать дальше...
by Anna N. Osiecka, Przemysław Bryndza, Elodie F. Briefer, Katarzyna Wojczulanis-Jakubas
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by Maciej Majka, Nils B. Becker, Pieter Rein ten Wolde, Marcin Zagorski, Thomas R. Sokolowski
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by Jan Stasinski, Halgurd Taher, Jil Mona Meier, Michael Schirner, Dionysios Perdikis, Petra Ritter
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by Lalit Pandey, Donsuk Lee, Samantha M. W. Wood, Justin N. Wood
How do newborns learn to see? We propose that visual systems are space-time fitters, meaning visual development can be understood as a blind fitting process (akin to evolution) in which visual systems gradually adapt to the spatiotemporal data distributions in the newborn’s environment. To test whether space-time fitting is a viable theory for learning how to see, we performed parallel controlled-rearing experiments on newborn chicks and deep neural networks (DNNs)... Читать дальше...
by Mark A. Orloff, Dongil Chung, Xiaosi Gu, Xingchao Wang, Zhixian Gao, Guiding Song, Chandana Tatineni, Shuai Xu, Brooks Casas, Pearl H. Chiu
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by Yuqian Liu, Yan Chen, Huanwen Wu, Xuanping Zhang, Yuqi Wang, Xin Yi, Zhiyong Liang, Jiayin Wang
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by Meng Yuan, Seppe Goovaerts, Michiel Vanneste, Harold Matthews, Hanne Hoskens, Stephen Richmond, Ophir D. Klein, Richard A. Spritz, Benedikt Hallgrimsson, Susan Walsh, Mark D. Shriver, John R. Shaffer, Seth M. Weinberg, Hilde Peeters, Peter Claes
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by Nisha Ann Viswan, Alexandre Tribut, Manvel Gasparyan, Ovidiu Radulescu, Upinder S. Bhalla
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by Adrián F. Amil, Albert Albesa-González, Paul F. M. J. Verschure
Theta-band oscillations (3–8 Hz) in the mammalian hippocampus organize the temporal structure of cortical inputs, resulting in a phase code that enables rhythmic input sampling for episodic memory formation and spatial navigation. However, it remains unclear what evolutionary pressures might have driven the selection of theta over higher-frequency bands that could potentially provide increased input sampling resolution. Here... Читать дальше...
by Michiel Vanslambrouck, Wim Thiels, Jef Vangheel, Casper van Bavel, Bart Smeets, Rob Jelier
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by Jonathan M. Werner, Jesse Gillis
Human neural organoids offer an exciting opportunity for studying inaccessible human-specific brain development; however, it remains unclear how precisely organoids recapitulate fetal/primary tissue biology. We characterize field-wide replicability and biological fidelity through a meta-analysis of single-cell RNA-sequencing data for first and second trimester human primary brain (2.95 million cells, 51 data sets) and neural organoids (1.59 million cells, 173 data sets). Читать дальше...
by Xin Yuan, Hailiang Li, Fang Guo
Organisms detect temperature signals through peripheral neurons, which relay them to central circadian networks to drive adaptive behaviors. Despite recent advances in Drosophila research, how circadian circuits integrate temperature cues with circadian signals to regulate sleep/wake patterns remains unclear. In this study, we used the FlyWire brain electron microscopy connectome to map neuronal connections, identifying lateral posterior neurons LPNs as... Читать дальше...