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Новости за 27.12.2024

Plos.org 
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Global burden of cardiovascular disease mortality attributable to secondhand smoke, 1990–2019: Systematic analysis of the Global Burden of Disease Study 2019

by Juan Dong, Xumin Ma, Xingxin Hu, Mengmeng Yan

Background

Few studies have globally assessed the cardiovascular disease (CVD) mortality burden attributable to secondhand smoke. We aimed to address this research gap.

Methods

We used a systematic analysis design using data from the Global Burden of Disease Study 2019. Our primary outcome measures were the age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years (DALYs) for CVD attributable to secondhand smoke. Читать дальше...

Plos.org 
En

Use of interactional metadiscourse and identity construction in responses to negative online reviews of Chinese and British hotels

by Jingjing Huang, Wei Xiao

In the business context, effectively responding to negative reviews is critical for a hotel to maintain reputation and customer relations. To explore the linguistic devices employed in addressing guest complaints, a corpus-based study is conducted on the use of interactional metadiscourse and identity construction in responses to negative online reviews of Chinese and British Hotels. Drawing upon the statistical results of the usage of interactional metadiscourse and the analysis of discourse examples... Читать дальше...

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Plos.org 
En

St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo

by Yanxia Guo, Shikang Wang, Qun Liu, Yan Dong, Yongqing Liu

Drug resistance of cancers remains a major obstacle due to limited therapeutics. Lysosome targeting is an effective method for overcoming drug resistance in cancer cells. St-N (ent-13-hydroxy-15-kaurene-19-acid N-methylpiperazine ethyl ester) is a novel alkaline stevioside derivative with an amine group. In this study, we found that docetaxel (Doc)-resistant prostate cancer (PCa) cells were sensitive to St-N. Mechanistically, the... Читать дальше...

Plos.org 
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AptaFluorescence: An aptamer-based fluorescent imaging protocol for biomolecule visualization

by Crystal Chia Yin Ling, Melissa Jane Fullwood

Immunofluorescence is highly dependent on antibody-antigen interactions for accurate visualization of proteins and other biomolecules within cells. However, obtaining antibodies with high specificity and affinity for their target proteins can be challenging, especially for targets that are complex or naturally present at low levels. Therefore, we developed AptaFluorescence, a protocol that utilizes fluorescently labeled aptamers for in vitro biomolecule visualization. Читать дальше...

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