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Новости за 07.01.2025

Plos.org 
En

Effects of the pan-caspase inhibitor Q-VD-OPh on human neutrophil lifespan and function

by Lisa Khuu, Alisha Pillay, Allan Prichard, Lee-Ann H. Allen

Human neutrophils are abundant, short-lived leukocytes that turn over at a rate of approximately 1011 cells/day via a constitutive apoptosis program. Certain growth factors, inflammatory mediators and infectious agents can delay apoptosis or induce neutrophils to die by other mechanisms. Nonetheless, a large body of data demonstrates that apoptosis of untreated neutrophils typically ensues within 24 hours of cell isolation and in vitro culture. Читать дальше...

Plos.org 
En

Association of varicose veins with the risk of heart failure: A nationwide cohort study

by Dongyeop Kim, Moo-Seok Park, Ju-young Park, Tae-Jin Song

Background

Research investigating the association between varicose veins (VV) and heart failure has been limited. Here, we examine this association within a nationwide longitudinal cohort, hypothesizing an increased risk of heart failure associated with the presence of VV.

Methods

Our study included 390,436 participants based on health screening results conducted from 2005 to 2010 in the South Korean health screening cohort database. Читать дальше...

Plos.org 
En

Research on boundary control of vehicle-mounted flexible manipulator based on partial differential equations

by Yuzhi Tang

Vehicle-mounted flexible robotic arms (VFRAs) are crucial in enhancing operational capabilities in sectors where human intervention is limited due to accessibility or safety concerns, such as hazardous environments or precision surgery. This paper introduces the latest generation of VFRAs that utilize advanced soft materials and are designed with elongated structures to provide greater flexibility and control. We present a novel mathematical model, derived using Hamilton’s principle... Читать дальше...

Дженнифер Лопес оставит себе обручальное кольцо от Бена Аффлека после развода
Особняки Пэрис Хилтон и Энтони Хопкинса уничтожил пожар
Названы два знака восточного зодиака, которых побалует фортуна с 10 по 20 января
Меган Маркл будет продавать продукцию своего бренда напрямую зрителям с помощью Netflix
Режиссер Тигран Кеосаян впал в кому
Раскрыт райдер Анжелики Варум для выступлений на корпоративах — жесткие условия
Plos.org 
En

Gender difference in domain-specific quality of life measured by modified WHOQoL-BREF questionnaire and their associated factors among older adults in a rural district in Bangladesh

by Fakir M. Amirul Islam

Background

The global population of older adults has steadily increased in recent decades. Little is known about the gender difference in the quality of life (QoL) of older adults in the general population. This study aimed to identify factors associated with QoL among older adults by gender.

Method

Data on QoL using the World Health Organization Quality of Life (WHOQoL-BREF) questionnaire and socio-demographic characteristics, including living status and sources of income... Читать дальше...

Слияние с исчезновениями // Т-Банк не полностью интегрировал средства клиентов Росбанка
Уссурийский ЛРЗ провел для будущих сварщиков мастер-класс
Туманность Ориона
Иногда мне кажется, что лучше ни с кем не заводить дружбу.
Уссурийский ЛРЗ провел для будущих сварщиков мастер-класс
Терпение лопнуло: В Москве детей иноземцев вышвырнули за шкирку с катка их сородичи хотят обратиться в суд
Plos.org 
En

Improving polygenic prediction from summary data by learning patterns of effect sharing across multiple phenotypes

by Deborah Kunkel, Peter Sørensen, Vijay Shankar, Fabio Morgante

Polygenic prediction of complex trait phenotypes has become important in human genetics, especially in the context of precision medicine. Recently, mr.mash, a flexible and computationally efficient method that models multiple phenotypes jointly and leverages sharing of effects across such phenotypes to improve prediction accuracy, was introduced. However, a drawback of mr.mash is that it requires individual-level data, which are often not publicly available. Читать дальше...

Plos.org 
En

Benchmarking uncertainty quantification for protein engineering

by Kevin P. Greenman, Ava P. Amini, Kevin K. Yang

Machine learning sequence-function models for proteins could enable significant advances in protein engineering, especially when paired with state-of-the-art methods to select new sequences for property optimization and/or model improvement. Such methods (Bayesian optimization and active learning) require calibrated estimations of model uncertainty. While studies have benchmarked a variety of deep learning uncertainty quantification (UQ) methods... Читать дальше...

Plos.org 
En

Intraneuronal binding of amyloid beta with reelin—Implications for the onset of Alzheimer’s disease

by Asgeir Kobro-Flatmoen, Stig W. Omholt

Numerous studies of the human brain supported by experimental results from rodent and cell models point to a central role for intracellular amyloid beta (Aβ) in the onset of Alzheimer’s disease (AD). In a rat model used to study AD, it was recently shown that in layer II neurons of the anteriolateral entorhinal cortex expressing high levels of the glycoprotein reelin (Re+alECLII neurons), reelin and Aβ engage in a direct protein–protein interaction. Читать дальше...