by Chamberline E. Ozigbu, Zhenlong Li, Bankole Olatosi, James W. Hardin, Nicole L. Hair
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by Martina Ferrari-Díaz, Ashuin Kammar-García, Juan Silva-Pereyra, Carmen García-Peña
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by Sofía I. Pacheco-Forés, Nicolas Gauthier, Lacey B. Carpenter, Gwyneth Gordon, Kelly J. Knudson
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by Hoda Abbasizanjani, Stuart Bedston, Ashley Akbari
ObjectivesWe developed an efficient Research-Ready Data Asset (RRDA) for the Welsh Longitudinal General Practice (WLGP) data within the Secure Anonymised Information Linkage Databank to standardise curation, enhance reproducibility, and facilitate research on primary care trends. Using this, we investigated primary care activity trends during and after the COVID-19 pandemic.
MethodsThe RRDA involves cleaning, curation using GP-registration history... Читать дальше...
by Linna Zhao, Juanjuan Zhang, Weizhe Liu, Cheng Dai, Aiying Li
Diabetes mellitus (DM) is identified as a potential modifier of clinical outcomes in acute heart failure (AHF), yet its prognostic impact is not fully determined. This systematic review and meta-analysis aimed to assess the prognostic impact of DM on survival outcomes in AHF patients by synthesizing evidence from 26 studies involving 326,928 subjects collected from Cochrane Library, PubMed, Web of Science, and Embase databases up to 1 June 2024. Читать дальше...
by Jonas Österlind, Johan Birnefeld, Elin Birnefeld, Magnus Hultin, Sara Qvarlander, Anders Wåhlin, Petter Holmlund, Laleh Zarrinkoob
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by Xueming Wang, Jianming Zheng, Tinggui Chen
This study investigates the effects of risk perception, buffering ability, self-organization ability and learning ability on the fishermens’ecological farming willingness in Yangtze River, China. Using the Yangtze River basin fishermen as a case study, this study simultaneously used the partial least squares structural equation model (PLS-SEM) and fuzzy-set qualitative comparative analysis (fs/QCA) to explore the linear and nonlinear dynamic impacts among the variables. Читать дальше...
by Yizhe Yang, Ruifeng Liang, Yan Luo, Doudou Zhu, Yi Liu, Yuyan Guo, Jiafen Zhang, Qiao Niu
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by Darren Curnoe, Mohammed S. Sauffi, Hsiao Mei Goh, Xue-feng Sun, Roshan Peiris
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by Motoharu Hamano, Kazuya Niki, Keiki Imamura, Ken Sasaki
The chemical composition of the venom in social Hymenoptera differs between castes and ages. Biogenic amines are contained in the venom of honey bees and may be physiologically effective to vertebrate predators and insects. This study quantified the concentrations of biogenic amines in venom and compared them between different castes and ages of honey bees. The concentrations of dopamine and N-acetyldopamine in venom were significantly... Читать дальше...
by Miriam Soledad Rolón, Antonieta Rojas de Arias, Myriam Velázquez, Milena Britos, Paola Arze Selich, Jorge Alfonso Ruiz Díaz, Oscar Salvioni Recalde, Stefania Fraenkel Cálcena, Ana Gómez Garay, Nidia Martínez Acosta, María Celeste Vega Gómez
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by Carl Boodman, Wilma van den Boogaard, Guido Benedetti, Federica Zamatto, Azzurra D’incà, Jovana Arsenijević, Tobias Janisch, Temmy Sunyoto, Corey Leclair
by Minying Li, Huan Huang, Dongmei Li, Judun Zheng, Yinghui Liu, Yangxia Chen, Zhenmou Xie, Liyan Xi, Hongfang Liu
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by Wei Feng, Zengming Zhang, Zeyu Chen, Li Wang, Mao Ye, Yusu Gu, Titania Huang, Harrison Ngo, Ju Chen
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by Brian L. Weiss, Fabian Gstöttenmayer, Erick Awuoche, Gretchen M. Smallenberger, Geoffrey M. Attardo, Francesca Scolari, Robert T. Koch, Daniel J. Bruzzese, Richard Echodu, Robert Opiro, Anna Malacrida, Adly M. M. Abd-Alla, Serap Aksoy
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by Gurvir Singh, Robert V. Skibbens
The cohesin complex is composed of core ring proteins (Smc1, Smc3 and Mcd1) and associated factors (Pds5, Scc3, and Rad61) that bind via Mcd1. Extrusion (looping from within a single DNA molecule) and cohesion (the tethering together of two different DNA molecules) underlie the many roles that cohesins play in chromosome segregation, gene transcription, DNA repair, chromosome condensation, replication fork progression, and genome organization. While cohesin... Читать дальше...
by Adhithi Lakshmikanthan, Minnie Kay, Pim J.A. Oomen
Biological sex plays a crucial role in the outcomes of cardiac health and therapies. Sex hormones are known to strongly influence cardiac remodeling through intracellular signaling pathways, yet their underlying mechanisms remain unclear. To address this need, we developed and validated a logic-based systems biology model of cardiomyocyte hypertrophy that, for the first time, incorporates the effects of both estradiol (E2) and testosterone... Читать дальше...
by Ian K. Gingerich, Brittany A. Goods, H. Robert Frost
Spatial transcriptomics (ST) provides critical insights into the spatial organization of gene expression, enabling researchers to unravel the intricate relationship between cellular environments and biological function. Identifying spatial domains within tissues is key to understanding tissue architecture and mechanisms underlying development and disease progression. Here, we present Randomized Spatial PCA (RASP), a novel spatially-aware dimensionality reduction method for ST data.
by Atser Damsma, Jonathan Cannon, Lauren K. Fink, Keith B. Doelling, Jessica A. Grahn, Henkjan Honing, Thomas Kaplan, Edward W. Large, Fleur L. Bouwer
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by Davide Luciano, F. Emil Thomasen, Kresten Lindorff-Larsen, Gaston Courtade
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by Emoke Bakos, Ádám Tiszlavicz, Viktor Szegedi, Abdennour Douida, Szabina Furdan, Daphne K. Welter, Jonathan M. Landry, Balazs Bende, Gabor Hutoczki, Pal Barzo, Gabor Tamas, Vladimir Benes, Attila Szucs, Karri Lamsa
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As investors turn to capital efficiency and sustainable scaling, there are lessons to be learned from the Southeast — where founders have long built successful companies by doing more with less.
Save more than 80% on a one-time Office license.
JSE-listed real estate investment trust (Reit) Growthpoint has launched the new R26-million Sandton Drive Link Bridge as part of a larger effort to enhance safety, accessibility and walkability for pedestrians moving through the busy intersection. The bridge, which took 18 years to complete from its initial conception in 2007, spans 106 m and provides a direct pedestrian route over Sandton drive between Growthpoint’s The Place office building, at 1 Sandton drive, and the Sandton City shopping centre.
When you crack open a pomegranate, you'll see it's full of numerous jewel-toned arils, but how many seeds does each fruit actually contain?
