Editorial expression of concern

On 10 May 2016, Science Signaling published the Research Article “Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease” by S. I. Alfonso et al. (

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). The editors have been made aware of accusations of data manipulation regarding fig. S1, which are being investigated. We are publishing this Editorial Expression of Concern to make readers aware of these accusations while we await the outcome of the investigation.