Hierarchical marker genes selection in scRNA-seq analysis
by Yutong Sun, Peng Qiu
When analyzing scRNA-seq data containing heterogeneous cell populations, an important task is to select informative marker genes to distinguish various cell clusters and annotate the clusters with biologically meaningful cell types. In existing analysis methods and pipelines, marker genes are typically identified using a one-vs-all strategy, examining differential expression between one cell cluster versus the combination of all other cell clusters. However, this strategy... Читать дальше...
